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LATERAL PARABRACHIAL SEROTONERGIC MECHANISMS - ANGIOTENSIN-INDUCED PRESSOR AND DRINKING RESPONSES

dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorJohnson, A. K.
dc.contributor.institutionUNIV IOWA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:26:30Z
dc.date.available2014-05-20T15:26:30Z
dc.date.issued1995-11-01
dc.description.abstractThis study investigated the effects of bilateral injections of serotonergic receptor ligands into the lateral parabrachial nucleus (LPBN) on the presser and dipsogenic responses induced by intracerebroventricular (icv) injection of angiotensin II (ANG II). Rats with stainless steel cannulas implanted bilaterally into the LPBN and into the left lateral ventricle were used to study icy ANG II-induced water intake and presser responses. Pretreatment with the serotonergic 5-HT1/5-HT2 receptor antagonist methysergide (1-8 mu g/200 nl) bilaterally injected into the LPBN increased the water intake induced by icv ANG II (50 ng/mu l) administered via the lateral ventricle, but pretreatment with methysergide (4 mu g/200 nl) did not change the presser response produced by icy ANG II. After bilateral injection of either serotonin (5-HT, 5 mu g/200 nl) or the serotonergic 5-HT2a/5-HT2c receptor agonist (+/-)-2,5-dimetoxy-4-iodoamphetamine hydrochloride (DOI; 0.5-10 mu g/200 nl) into the LPBN, the water intake induced by ANG II was significantly reduced. These results are consistent with other observations indicating that the LPBN is associated with inhibitory mechanisms controlling water intake induced by ANG II treatment and suggest that serotonergic pathways may be involved in this effect.en
dc.description.affiliationUNIV IOWA, DEPT PSYCHOL, IOWA CITY, IA 52242 USA
dc.description.affiliationUNIV IOWA, DEPT PHARMACOL, IOWA CITY, IA 52242 USA
dc.description.affiliationUNIV IOWA, CTR CARDIOVASC, IOWA CITY, IA 52242 USA
dc.description.affiliationPAULISTA STATE UNIV, SCH DENT, DEPT PHYSIOL, BR-14801903 ARARAQUARA, SP, BRAZIL
dc.description.affiliationUnespPAULISTA STATE UNIV, SCH DENT, DEPT PHYSIOL, BR-14801903 ARARAQUARA, SP, BRAZIL
dc.format.extentR1044-R1049
dc.identifierhttp://ajpregu.physiology.org/content/269/5/R1044
dc.identifier.citationAmerican Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 269, n. 5, p. R1044-R1049, 1995.
dc.identifier.issn0363-6119
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/36673
dc.identifier.wosWOS:A1995TF10700014
dc.language.isoeng
dc.publisherAmer Physiological Soc
dc.relation.ispartofAmerican Journal of Physiology: Regulatory Integrative and Comparative Physiology
dc.relation.ispartofjcr3.082
dc.relation.ispartofsjr1,550
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectLATERAL PARABRACHIAL NUCLEUSpt
dc.subjectANGIOTENSIN IIpt
dc.subjectWATER INTAKEpt
dc.subjectARTERIAL PRESSUREpt
dc.subjectSEROTONINpt
dc.titleLATERAL PARABRACHIAL SEROTONERGIC MECHANISMS - ANGIOTENSIN-INDUCED PRESSOR AND DRINKING RESPONSESen
dc.typeArtigo
dcterms.licensehttp://www.the-aps.org/mm/Publications/Info-For-Authors/Copyright
dcterms.rightsHolderAmer Physiological Soc
dspace.entity.typePublication
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0003-1167-4441[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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