The deep mycoses in HIV infection

The deep mycoses are uncommon infections, usually acquired from the inhalation or ingestion of fungal spores, sometimes from the soil in areas of endemicity, such as in the Americas and south-east Asia, or from decaying vegetable matter. They are also seen in immunocompromised persons and, increasingly, in HIV-infected persons. Respiratory involvement is frequent, with granuloma formation, and mucocutaneous involvement may be seen. Oral lesions of the deep mycoses are typically chronic but non-specific, though nodular or ulcerative appearances are common. Person-to-person transmission is rare. In HIV disease, the most common orofacial involvement of deep mycoses has been in histoplasmosis, cryptococcosis, aspergillosis and zygomycosis. Diagnosis is usually confirmed by lesional biopsy although culture may also be valuable. Treatment is with amphotericin or an azole.

Keywords

HIV, Mycoses, Oral, amphotericin b, cotrimazine, fluconazole, flucytosine, itraconazole, ketoconazole, miconazole, rifampicin, sulfamethoxypyridazine, aspergillosis, biopsy, blastomycosis, coccidioidomycosis, conference paper, cryptococcosis, fungus culture, histoplasmosis, human, human immunodeficiency virus infection, immune deficiency, intravenous drug administration, lung granuloma, mucormycosis, mycosis, oral drug administration, priority journal, serodiagnosis, side effect, south american blastomycosis, Acquired Immunodeficiency Syndrome, Adult, AIDS-Related Opportunistic Infections, Amphotericin B, Aspergillosis, Azoles, Cryptococcosis, Female, Histoplasmosis, HIV Infections, Humans, Lung Diseases, Fungal, Male, Middle Aged, Mouth Diseases, Mucormycosis, Sinusitis