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First cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (acai) in cultured human cells

dc.contributor.authorMarques, E. S. [UNESP]
dc.contributor.authorTsuboy, M. S. F. [UNESP]
dc.contributor.authorCarvalho, J. C. T.
dc.contributor.authorRosa, P. C. P.
dc.contributor.authorPerazzo, F. F.
dc.contributor.authorGaivao, I. O. M.
dc.contributor.authorMaistro, E. L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Fed Amapa
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTras Os Montes & Alto Douro Univ
dc.date.accessioned2018-11-26T17:42:40Z
dc.date.available2018-11-26T17:42:40Z
dc.date.issued2017-08-18
dc.description.abstractEuterpe oleracea Mart., popularly known as acai, is a tropical fruit from the Amazon region where it has considerable economic importance. Acai has been used as food and for several medicinal purposes. Despite the widespread use of this fruit, there is a lack of data regarding the safety of using this fruit oil exclusively. Therefore, we evaluated the in vitro cytotoxic, genotoxic, and antigenotoxic effects of E. oleracea fruit oil (EOO) in cultured human lymphocytes (non-metabolizing cells) and HepG2 cell line (human hepatoma) (metabolizing cells) by using MTT, comet, and micronucleus assays. A wide range of EOO concentrations was tested with a preliminary MTT assay, which allowed selecting five concentrations for comet and micronucleus assays: 2.5, 10, 100, 500, and 1000 mu g/mL. The results showed that none of the EOO tested concentrations presented cytotoxic effects. The genotoxic assessment revealed an absence of significant DNA and chromosome damage in human lymphocytes and HepG2 cells but did not show chemoprotection against the DNA damage induced by methyl methanesulfonate and benzo[a] pyrene, used as DNA-damaging agents.en
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Programa Posgrad Biol Geral & Aplicada, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias & Letras, Dept Biotecnol, Assis, SP, Brazil
dc.description.affiliationUniv Fed Amapa, Colegiado Farm, Ctr Ciencias Biol & Saude, Lab Pesquisa Farmacos, Macapa, AP, Brazil
dc.description.affiliationUniv Estadual Campinas, Fac Ciencias Med, Campinas, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Dept Ciencias Exatas & Terra, Diadema, SP, Brazil
dc.description.affiliationTras Os Montes & Alto Douro Univ, CECAV, Vila Real, Portugal
dc.description.affiliationTras Os Montes & Alto Douro Univ, Dept Genet & Biotechnol, Vila Real, Portugal
dc.description.affiliationUniv Estadual Paulista, Fac Filosofia & Ciencia, Dept Fonoaudiol, Marilia, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Programa Posgrad Biol Geral & Aplicada, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias & Letras, Dept Biotecnol, Assis, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Filosofia & Ciencia, Dept Fonoaudiol, Marilia, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2012/17241-8
dc.format.extent11
dc.identifierhttp://dx.doi.org/10.4238/gmr16039700
dc.identifier.citationGenetics And Molecular Research. Ribeirao Preto: Funpec-editora, v. 16, n. 3, 11 p., 2017.
dc.identifier.doi10.4238/gmr16039700
dc.identifier.issn1676-5680
dc.identifier.urihttp://hdl.handle.net/11449/163590
dc.identifier.wosWOS:000417364500008
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics And Molecular Research
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAcai oil
dc.subjectArecaceae
dc.subjectComet assay
dc.subjectHepG2 cells
dc.subjectMicronucleus test
dc.titleFirst cytotoxic, genotoxic, and antigenotoxic assessment of Euterpe oleracea fruit oil (acai) in cultured human cellsen
dc.typeArtigo
dcterms.rightsHolderFunpec-editora
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Filosofia e Ciências, Maríliapt
unesp.departmentFonoaudiologia - FFCpt

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