Publicação:
Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens

dc.contributor.authorResende, Flavia A. [UNESP]
dc.contributor.authorSilva Almeida, Carolina P. da [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:11:43Z
dc.date.available2014-12-03T13:11:43Z
dc.date.issued2014-07-15
dc.description.abstractThe antimutagenicity of ten flavonoids, differing in their hydroxylation patterns against direct-acting and indirect-acting mutagens, namely 4-nitro-o-phenylenediamine, sodium azide, mitomycin C, benzo[a]pyrene, aflatoxin B-1 and 2-aminofluorene, were compared with the aim of investigating how the hydroxyl groups in their structures govern the biological activity of flavonoids, by the Ames test, with Salmonella typhimurium strains TA98, TA100 and TA102. The flavonoids tested were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In these tests, all compounds were shown to be antimutagenic in more than one strain and various mechanisms of action were demonstrated. The results suggested that the number and position of hydroxyl groups may increase or decrease the protective effect, depending on the type and concentration of flavonoids and mutagen used. These studies contribute to clarifying the mechanisms by which these flavonoids act in protecting DNA from damage. This is required before they can be widely used. (C) 2014 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUNESP Sao Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP Sao Paulo State Univ, BR-11330900 Sao Vicente, SP, Brazil
dc.description.affiliationUnespUNESP Sao Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP Sao Paulo State Univ, BR-11330900 Sao Vicente, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent251-255
dc.identifierhttp://dx.doi.org/10.1016/j.foodchem.2014.01.071
dc.identifier.citationFood Chemistry. Oxford: Elsevier Sci Ltd, v. 155, p. 251-255, 2014.
dc.identifier.doi10.1016/j.foodchem.2014.01.071
dc.identifier.issn0308-8146
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/113456
dc.identifier.wosWOS:000333730000037
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofFood Chemistry
dc.relation.ispartofjcr4.946
dc.relation.ispartofsjr1,793
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectFlavonoidsen
dc.subjectAntimutagenicityen
dc.subjectAmes testen
dc.titleDifferences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagensen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0002-9432-5919[1]
unesp.author.orcid0000-0003-3032-2556[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicentept
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentCiências Biológicas - IBCLPpt

Arquivos