Publicação: Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens
dc.contributor.author | Resende, Flavia A. [UNESP] | |
dc.contributor.author | Silva Almeida, Carolina P. da [UNESP] | |
dc.contributor.author | Vilegas, Wagner [UNESP] | |
dc.contributor.author | Varanda, Eliana Aparecida [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-12-03T13:11:43Z | |
dc.date.available | 2014-12-03T13:11:43Z | |
dc.date.issued | 2014-07-15 | |
dc.description.abstract | The antimutagenicity of ten flavonoids, differing in their hydroxylation patterns against direct-acting and indirect-acting mutagens, namely 4-nitro-o-phenylenediamine, sodium azide, mitomycin C, benzo[a]pyrene, aflatoxin B-1 and 2-aminofluorene, were compared with the aim of investigating how the hydroxyl groups in their structures govern the biological activity of flavonoids, by the Ames test, with Salmonella typhimurium strains TA98, TA100 and TA102. The flavonoids tested were: quercetin, kaempferol, luteolin, fisetin, chrysin, galangin, flavone, 3-hydroxyflavone, 5-hydroxyflavone and 7-hydroxyflavone. In these tests, all compounds were shown to be antimutagenic in more than one strain and various mechanisms of action were demonstrated. The results suggested that the number and position of hydroxyl groups may increase or decrease the protective effect, depending on the type and concentration of flavonoids and mutagen used. These studies contribute to clarifying the mechanisms by which these flavonoids act in protecting DNA from damage. This is required before they can be widely used. (C) 2014 Elsevier Ltd. All rights reserved. | en |
dc.description.affiliation | UNESP Sao Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliation | UNESP Sao Paulo State Univ, BR-11330900 Sao Vicente, SP, Brazil | |
dc.description.affiliationUnesp | UNESP Sao Paulo State Univ, Fac Pharmaceut Sci Araraquara, Dept Biol Sci, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | UNESP Sao Paulo State Univ, BR-11330900 Sao Vicente, SP, Brazil | |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.format.extent | 251-255 | |
dc.identifier | http://dx.doi.org/10.1016/j.foodchem.2014.01.071 | |
dc.identifier.citation | Food Chemistry. Oxford: Elsevier Sci Ltd, v. 155, p. 251-255, 2014. | |
dc.identifier.doi | 10.1016/j.foodchem.2014.01.071 | |
dc.identifier.issn | 0308-8146 | |
dc.identifier.lattes | 7927877224326837 | |
dc.identifier.orcid | 0000-0003-3032-2556 | |
dc.identifier.uri | http://hdl.handle.net/11449/113456 | |
dc.identifier.wos | WOS:000333730000037 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Food Chemistry | |
dc.relation.ispartofjcr | 4.946 | |
dc.relation.ispartofsjr | 1,793 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Web of Science | |
dc.subject | Flavonoids | en |
dc.subject | Antimutagenicity | en |
dc.subject | Ames test | en |
dc.title | Differences in the hydroxylation pattern of flavonoids alter their chemoprotective effect against direct- and indirect-acting mutagens | en |
dc.type | Artigo | |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
dspace.entity.type | Publication | |
unesp.author.lattes | 7927877224326837 | |
unesp.author.orcid | 0000-0002-9432-5919[1] | |
unesp.author.orcid | 0000-0003-3032-2556[3] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Biociências, São Vicente | pt |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Ciências Biológicas - FCF | pt |
unesp.department | Ciências Biológicas - IBCLP | pt |