Perfusão cerebral e análise individual automatizada utilizando SPECT em uma população com transtorno obsessivo-compulsivo
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Coorientador
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Curso de graduação
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FapUNIFESP (SciELO)
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Artigo
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Acesso aberto
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Resumo
Objective: To make individual assessments using automated quantification methodology in order to screen for perfusion abnormalities in cerebral SPECT examinations among a sample of subjects with OCD. Methods: Statistical parametric mapping (SPM) was used to compare 26 brain SPECT images from patients with OCD individually with an image bank of 32 normal subjects, using the statistical threshold of p < 0.05 (corrected for multiple comparisons at the level of individual voxels or clusters). The maps were analyzed, and regions presenting voxels that remained above this threshold were sought. results: Six patients from a sample of 26 OCD images showed abnormalities at cluster or voxel level, considering the criteria described above, which represented 23.07%. However, seven images from the normal group of 32 were also indicated as cases of perfusional abnormality, representing 21.8% of the sample. Conclusion: The automated quantification method was not considered to be a useful tool for clinical practice, for analyses complementary to visual inspection.
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Palavras-chave
Brain SPECT , Individual analysis , OCD , SPM , cysteine ethyl ester tc 99m , adult , automation , brain mapping , brain perfusion , clinical article , clinical assessment , controlled study , female , human , image processing , male , obsessive compulsive disorder , prediction , single photon emission computer tomography
Idioma
Português
Citação
Jornal Brasileiro de Psiquiatria, v. 60, n. 1, p. 1-6, 2011.
