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Toxicologic evaluation of acute and subacute oral administration of Cucurbita maxima seed extracts to rats and swine

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dc.contributor.authorQueiroz-Neto, Antonio de
dc.contributor.authorMataqueiro, Maria Isabel
dc.contributor.authorSantana, Aureo Evangelista
dc.contributor.authorAlessi, Antonio Carlos
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:17:57Z
dc.date.available2014-05-27T11:17:57Z
dc.date.issued1994-07-04
dc.description.abstractThe extract prepared from dried seeds of Cucurbita maxima was administered to rats and pigs. Following a single dose or 4 weeks of daily oral administration, the extract produced no changes in serum glucose, urea, creatinine, total protein, uric acid, GOT, GPT, LDH or blood counts. Urine analysis (urea, uric acid, creatinine, total protein, Na and K), as well as histopathological investigation, showed no abnormalities. These results taken as a whole indicate that the seeds of C. maxima as used in Brazilian folk medicine are not toxic for rats and swine.en
dc.description.affiliationDepartamento de Morfologia e Fisiologia Animal
dc.description.affiliationDepartamento de Clinica e Cirurgia Veterinária
dc.description.affiliationDepartamento de Patologia Veterinária Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, São Paulo
dc.format.extent45-51
dc.identifierhttp://dx.doi.org/10.1016/0378-8741(94)90115-5
dc.identifier.citationJournal of Ethnopharmacology, v. 43, n. 1, p. 45-51, 1994.
dc.identifier.doi10.1016/0378-8741(94)90115-5
dc.identifier.issn0378-8741
dc.identifier.lattes8905659987198068
dc.identifier.scopus2-s2.0-0028363013
dc.identifier.urihttp://hdl.handle.net/11449/64490
dc.language.isoeng
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCucurbita maxima
dc.subjectPumpkin
dc.subjectToxicity
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectcreatinine
dc.subjectglucose
dc.subjectlactate dehydrogenase
dc.subjectplant extract
dc.subjectprotein
dc.subjecturea
dc.subjecturic acid
dc.subjectaminotransferase blood level
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectblood cell count
dc.subjectcontrolled study
dc.subjectcreatinine blood level
dc.subjectcreatinine urine level
dc.subjectdrug safety
dc.subjectfemale
dc.subjectglucose blood level
dc.subjectlactate dehydrogenase blood level
dc.subjectnonhuman
dc.subjectoral drug administration
dc.subjectpotassium urine level
dc.subjectprotein urine level
dc.subjectrat
dc.subjectsodium urine level
dc.subjectswine
dc.subjecttraditional medicine
dc.subjecturea blood level
dc.subjecturic acid blood level
dc.subjecturic acid urine level
dc.subjecturinalysis
dc.subjectweight gain
dc.subjectAdministration, Oral
dc.subjectAnimal
dc.subjectBlood Cell Count
dc.subjectBlood Glucose
dc.subjectBlood Proteins
dc.subjectBrazil
dc.subjectCreatinine
dc.subjectDrug Evaluation, Preclinical
dc.subjectElectrolytes
dc.subjectFemale
dc.subjectHeart
dc.subjectKidney
dc.subjectLiver
dc.subjectLung
dc.subjectPancreas
dc.subjectPlant Extracts
dc.subjectRandom Allocation
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSeeds
dc.subjectSpleen
dc.subjectSupport, Non-U.S. Gov't
dc.subjectSwine
dc.subjectUrea
dc.subjectUric Acid
dc.titleToxicologic evaluation of acute and subacute oral administration of Cucurbita maxima seed extracts to rats and swineen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dspace.entity.typePublication
unesp.author.lattes8905659987198068[3]
unesp.author.orcid0000-0003-4539-1802[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentPatologia Veterinária - FCAVpt

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Jaboticabal - FCAV - Faculdade de Ciências Agrárias e Veterinárias