Efficacy of Carisolv™ as an adjunctive therapy to scaling and root planing on subgingival calculus removal

The purpose of this study was to evaluate the effectiveness of subgingival application of Carisolv™ gel as an adjunctive therapy to scaling and root planing (SRP) on calculus removal compared to conventional instrumentation. Forty-five teeth requiring extraction due to severe periodontal disease were randomized to the following treatments: 1) SRP alone; 2) placebo gel + SRP; 3) Carisolv™ gel + SRP. Either test or placebo gel was applied subgingivally for 1 min and then the root were instrumented until a smooth and calculus-free surface was achieved. Instrumentation time and the number of strokes required were recorded. After extraction, the efficacy of root surface instrumentation was measured by percentage of remaining calculus. There was no statistically significant difference (p>0.05) between the treatment groups regarding either time required for instrumentation or the percentage of residual calculus. The subgingival application of Carisolv™ gel prior to SRP did not provide any additional benefit to root instrumentation compared to scaling and root planing alone.

Keywords

Calculus, Carisolv™, Periodontal treatment, Scaling and root planing, Carisolv, glutamic acid, leucine, lysine, placebo, solvent, unclassified drug, adult, clinical trial, comparative study, controlled clinical trial, controlled study, female, human, image processing, instrumentation, male, medical photography, methodology, preventive dentistry, randomized controlled trial, time, tooth calculus, treatment outcome, Adult, Dental Calculus, Dental Scaling, Female, Glutamic Acid, Humans, Image Processing, Computer-Assisted, Leucine, Lysine, Male, Photography, Dental, Placebos, Root Planing, Solvents, Time Factors, Treatment Outcome