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Nutritional status and immune response in murine experimental Jorge Lobo's disease

dc.contributor.authorBarbosa, Adriana Sierra Assencio Almeida
dc.contributor.authorDiório, Suzana Madeira
dc.contributor.authorPedrini, Silvia Cristina Barboza
dc.contributor.authorSilva, Sônia Maria Uso Ruiz
dc.contributor.authorSartori, Beatriz Gomes Carreira
dc.contributor.authorCalvi, Sueli Aparecida [UNESP]
dc.contributor.authorPereira, Paulo Câmara Marques [UNESP]
dc.contributor.authorVilani-Moreno, Fátima Regina
dc.contributor.institutionInstituto Lauro de Souza Lima
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:31:33Z
dc.date.available2015-12-07T15:31:33Z
dc.date.issued2015
dc.description.abstractThere are no studies investigating the role of nutritional status and immunity associated with Jorge Lobo's disease. The objective of this study was to evaluate the effects of protein-calorie malnutrition on the immune response of BALB/c mice inoculated with Lacazia loboi. In this study,the animals were divided into four groups: G1: inoculated with restricted diet, G2: not inoculated with restricted diet, G3: inoculated with regular diet, G4: not inoculated with regular diet. The animals of groups G1 and G2 were submitted to malnutrition for 20 days and once installed the animals were inoculated intradermally into the footpad. After 4 months, they were euthanised for the isolation of peritoneal lavage cells and removal of the footpad. The production of IL-2, IL-4, IL-10, IL-12, IFN-γ, TNF-α, H2 O2 and nitric oxide (NO) was evaluated in the peritoneal lavage cells. The footpad was evaluated regarding the size of macroscopic lesions, number of fungi and viability index. The results showed that the infection did not exert great influence on the body weight of the mice and previous malnutrition was an unfavourable factor for viability index, number of fungi, macroscopic lesion size in the footpad and production of H2 O2 , NO, IL-12, IL-10 and IFN-γ, suggesting that malnutrition significantly altered fungal activity and peritoneal cells. The results suggest considerable interaction between nutrition and immunity in Jorge Lobo's disease.en
dc.description.affiliationBiology Technical Team, Instituto Lauro de Souza Lima, Bauru, Brazil.
dc.description.affiliationMicrobiology Technical Team, Instituto Lauro de Souza Lima, Bauru, Brazil.
dc.description.affiliationAnimal House, Instituto Lauro de Souza Lima, Bauru, Brazil.
dc.description.affiliationDepartment of Tropical Diseases, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, Brazil.
dc.description.affiliationUnespDepartment of Tropical Diseases, Botucatu Medical School, São Paulo State University, UNESP, Botucatu, Brazil.
dc.format.extent522-530
dc.identifierhttp://dx.doi.org/10.1111/myc.12351
dc.identifier.citationMycoses, v. 58, n. 9, p. 522-530, 2015.
dc.identifier.doi10.1111/myc.12351
dc.identifier.issn1439-0507
dc.identifier.lattes2179450022699059
dc.identifier.lattes1365320427418204
dc.identifier.orcid0000-0001-5771-8943
dc.identifier.pubmed26156007
dc.identifier.urihttp://hdl.handle.net/11449/131096
dc.language.isoeng
dc.publisherBlackwell Verlag GmbH
dc.relation.ispartofMycoses
dc.relation.ispartofsjr1,069
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectJorge lobo′s diseaseen
dc.subjectLacazia loboien
dc.subjectImmune responseen
dc.subjectMalnutritionen
dc.subjectMiceen
dc.titleNutritional status and immune response in murine experimental Jorge Lobo's diseaseen
dc.typeArtigo
dcterms.rightsHolderBlackwell Verlag GmbH
dspace.entity.typePublication
unesp.author.lattes2179450022699059
unesp.author.lattes1365320427418204[7]
unesp.author.orcid0000-0001-5771-8943[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentDoenças Tropicais e Diagnósticos por Imagem - FMBpt

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