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Action of nicotine and ovariectomy on bone regeneration after tooth extraction in rats

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dc.contributor.authorRibeiro Machado, Giscard Jose [UNESP]
dc.contributor.authorDamasio Dias, Sheila Monica [UNESP]
dc.contributor.authorBosco, Álvaro Francisco [UNESP]
dc.contributor.authorOkamoto, Tetuo [UNESP]
dc.contributor.authorBedran de Castro, Joao Cesar [UNESP]
dc.contributor.authorDornelles, Rita Cassia Menegati [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:26Z
dc.date.accessioned2014-05-20T13:43:00Z
dc.date.available2013-09-30T18:29:26Z
dc.date.available2014-05-20T13:43:00Z
dc.date.issued2010-11-01
dc.description.abstractPurpose: The purpose of this study was to evaluate the effects of nicotine and ovariectomy on alveolar bone regeneration after exodontias in rats.Materials and Methods: For 30 days, sham ovariectomized (OVX)/NaCl, sham OVX/nicotine, OVX/NaCl, and OVX/nicotine animals were given 2 daily injections of saline or hemisulfate of nicotine. After this period, exodontic procedures were carried out and treatment continued up to the time of euthanasia on clays 7 and 14 when the alveoli were removed for further analyses.Results: The data confirmed that nicotine significantly delays the alveolar regeneration process after dental extraction in rats and showed that the association of nicotine with ovariectomy exacerbates these results.Conclusion: These results indicate that nicotine potentiated the effect of estrogen deficiency on bone regeneration induced by ovariectomy. (c) 2010 American Association of Oral and Maxillofacial Surgeons Oral Maxillofac Surg 68:2675-2681, 2010en
dc.description.affiliationUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, São Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Dept Surg, São Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Integrated Clin, São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Dept Basic Sci, São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Dept Surg, São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dent Sch Aracatuba, Integrated Clin, São Paulo, Brazil
dc.format.extent2675-2681
dc.identifierhttp://dx.doi.org/10.1016/j.joms.2010.04.018
dc.identifier.citationJournal of Oral and Maxillofacial Surgery. Philadelphia: W B Saunders Co-elsevier Inc, v. 68, n. 11, p. 2675-2681, 2010.
dc.identifier.doi10.1016/j.joms.2010.04.018
dc.identifier.issn0278-2391
dc.identifier.lattes9831236034935598
dc.identifier.lattes0169955363968097
dc.identifier.lattes5435902422784889
dc.identifier.orcid0000-0003-0783-6612
dc.identifier.urihttp://hdl.handle.net/11449/14957
dc.identifier.wosWOS:000283971400006
dc.language.isoeng
dc.publisherW B Saunders Co-elsevier Inc
dc.relation.ispartofJournal of Oral and Maxillofacial Surgery
dc.relation.ispartofjcr1.779
dc.relation.ispartofsjr0,967
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.titleAction of nicotine and ovariectomy on bone regeneration after tooth extraction in ratsen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderW B Saunders Co-elsevier Inc
dspace.entity.typePublication
relation.isOrgUnitOfPublication8b3335a4-1163-438a-a0e2-921a46e0380d
relation.isOrgUnitOfPublication.latestForDiscovery8b3335a4-1163-438a-a0e2-921a46e0380d
unesp.author.lattes9831236034935598
unesp.author.lattes0169955363968097
unesp.author.lattes5435902422784889[6]
unesp.author.orcid0000-0003-0783-6612[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentCirurgia e Clínica Integrada - FOApt
unesp.departmentCiências Básicas - FOApt

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Araçatuba - FOA - Faculdade de Odontologia