Avaliação da resposta biológica inflamatória e capacidade de biomineralização de cimentos endodônticos resinosos obturadores
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Data
Autores
Orientador
Bueno, Carlos Roberto Emerenciano 
Coorientador
Pós-graduação
Curso de graduação
Araçatuba - FOA - Odontologia
Título da Revista
ISSN da Revista
Título de Volume
Editor
Universidade Estadual Paulista (Unesp)
Tipo
Trabalho de conclusão de curso
Direito de acesso
Acesso restrito
Resumo
Resumo (português)
The obturation of the root canal system aims to fill empty spaces previously occupied by the root pulp, aiming for a hermetic seal and providing conditions for repair and biological sealing through the biomineralization process. Therefore, characteristics such as biocompatibility and inducing the deposition of mineralized tissue (biomineralization) are fundamental for obturation cements, since they will be in direct contact with periapical tissues. This study evaluated the inflammatory response and mineralization induction of 3 resin-based endodontic obturation cements. Twenty Wistar rats were used, receiving 3 subcutaneous implants of polyethylene tubes containing Endosealer, Endosealer Plus, and Endosealer Premium cements, and an empty tube as a control (n=10 animals/group). After 7 and 30 days, the animals were euthanized, and the polyethylene tubes were removed along with the adjacent tissues. Inflammatory infiltrate and fibrous capsule thickness were histologically evaluated by assigning inflammatory scores (scores 0, 1, 2, and 3) according to the intensity of the inflammation. The presence of mineralized tissue was assessed by Von Kossa staining and without staining for analysis of birefringent crystals under polarized light. In the initial periods, all groups showed inflammation score 2 with a thick fibrous capsule that regressed after 30 days, surrounded by a thin fibrous capsule. Von Kossa staining and polarized light were negative for all groups in both experimental periods. The resin obturation sealers tested were biocompatible but did not induce biomineralization.
Resumo (inglês)
The obturation of the root canal system aims to fill empty spaces previously occupied by the root pulp, aiming for a hermetic seal and providing conditions for repair and biological sealing through the biomineralization process. Therefore, characteristics such as biocompatibility and inducing the deposition of mineralized tissue (biomineralization) are fundamental for obturation cements, since they will be in direct contact with periapical tissues. This study evaluated the inflammatory response and mineralization induction of 3 resin-based endodontic obturation cements. Twenty Wistar rats were used, receiving 3 subcutaneous implants of polyethylene tubes containing Endosealer, Endosealer Plus, and Endosealer Premium cements, and an empty tube as a control (n=10 animals/group). After 7 and 30 days, the animals were euthanized, and the polyethylene tubes were removed along with the adjacent tissues. Inflammatory infiltrate and fibrous capsule thickness were histologically evaluated by assigning inflammatory scores (scores 0, 1, 2, and 3) according to the intensity of the inflammation. The presence of mineralized tissue was assessed by Von Kossa staining and without staining for analysis of birefringent crystals under polarized light. In the initial periods, all groups showed inflammation score 2 with a thick fibrous capsule that regressed after 30 days, surrounded by a thin fibrous capsule. Von Kossa staining and polarized light were negative for all groups in both experimental periods. The resin obturation sealers tested were biocompatible but did not induce biomineralization.
Descrição
Palavras-chave
Biomineralização, Endodontia, Inflamação, Restaurações (Odontologia), Endodontics
Idioma
Português
Citação
SOBRAL, L.B. Avaliação da resposta biológica inflamatória e capacidade de biomineralização de cimentos endodônticos resinosos obturadores. 2026. Trabalho de Conclusão de Curso (Bacharelado em Odontologia) - Faculdade de Odontologia, Universidade Estadual Paulista (UNESP), Araçatuba, 2026.
