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Genetic association study between Interleukin 10 gene and dental implant loss

dc.contributor.authorPigossi, Suzane C. [UNESP]
dc.contributor.authorAlvim-Pereira, Fabiano
dc.contributor.authorMontes, Claudia C.
dc.contributor.authorFinoti, Livia S. [UNESP]
dc.contributor.authorSecolin, Rodrigo
dc.contributor.authorTrevilatto, Paula C.
dc.contributor.authorScarel-Caminaga, Raquel M. [UNESP]
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionPontifícia Universidade Católica do Paraná (PUCPR)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:49Z
dc.date.available2014-05-20T13:46:49Z
dc.date.issued2012-09-01
dc.description.abstractObjective: Three single nucleotide polymorphisms (SNPs), -1082, -819 and -592, located on the promoter region of IL10 gene have been associated with high in vitro IL-10 production and autoimmune diseases. We aim to investigate whether polymorphisms in the IL10 gene would influence dental implant loss.Methods: We evaluated a total of 277 unrelated patients, including 185 individuals presenting at least one osseointegrated implant in function for six months or more and with no implant failure, and 92 individuals presenting at least one implant loss. DNA was extracted from buccal mucosa cells and SNPs were genotyped using TaqMan (R) probes-based assays.Results: Multiple logistic regression showed association between dental implant failure with -819(C/T) genotype (OR = 3.27; 95% CI = 1.02-10.46; p = 0.0334). However, considering the statistical significance level alpha = 0.004 (adjusted by Bonferroni correction of multiple comparisons), these results lost their significance. No association of dental implant loss with genotypes and alleles of the -1082 and -592 SNPs, as well as IL10 haplotypes in genotype/allele forms were found (p = 0.9400; p = 0.8861).Conclusions: Neither the IL10 gene polymorphisms, nor haplotypes or other covariates were associated with susceptibility to dental implant failure in the studied population. (C) 2012 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Fed Sergipe, Dept Hlth Sci, Lagarto, SE, Brazil
dc.description.affiliationUniv Campinas UNICAMP, Dept Med Genet, Campinas, SP, Brazil
dc.description.affiliationPontificia Univ Catolica Parana PUCPR, Ctr Hlth & Biol Sci, Curitiba, PR, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 09/09932-8
dc.format.extent1256-1263
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2012.02.020
dc.identifier.citationArchives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 9, p. 1256-1263, 2012.
dc.identifier.doi10.1016/j.archoralbio.2012.02.020
dc.identifier.issn0003-9969
dc.identifier.urihttp://hdl.handle.net/11449/16596
dc.identifier.wosWOS:000308974800015
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofArchives of Oral Biology
dc.relation.ispartofjcr2.050
dc.relation.ispartofsjr0,752
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectDental implantsen
dc.subjectGenetic susceptibilityen
dc.subjectRisk factorsen
dc.subjectPolymorphismsen
dc.titleGenetic association study between Interleukin 10 gene and dental implant lossen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dspace.entity.typePublication
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.author.orcid0000-0001-5781-8629[6]
unesp.author.orcid0000-0002-2485-9560[5]
unesp.author.orcid0000-0001-7067-6119[1]
unesp.author.orcid0000-0001-8459-267X[2]
unesp.author.orcid0000-0001-5068-0268[7]
unesp.author.orcid0000-0002-3389-4026[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentMorfologia - FOARpt

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