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Exposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina C

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dc.contributor.authorViveiros, Magda Massae Hata [UNESP]
dc.contributor.authorSchellini, Silvana Artioli [UNESP]
dc.contributor.authorCandeias, João [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T20:16:09Z
dc.date.available2022-04-28T20:16:09Z
dc.date.issued2007-01-01
dc.description.abstractPurpose: To evaluate the fibroblast proliferation activity of normal Tenon's capsule from primary and recurrent patients with pterygium. Methods: A randomized prospective study was performed with 41 normal Tenon's capsule fragments from 21 primary and 20 recurrent patients with pterygium. The sample was collected from the inferior cul-de-sac. Proliferation rate from fibroblasts were evaluated after mitomycin C and 5-fluorouracil exposition. Data were submitted to statistical analysis. Results: Of the 41 cultivated normal Tenon's capsules, only 1 from primary and 2 from recurrent pterygium patients proliferated. After antimitotic exposition, the proliferation rate was similar with both drugs. Conclusion: Mitomycin and 5-fluorouracil promote similar inhibition regarding proliferation of normal Tenon's fibroblast cultures.en
dc.description.affiliationDepartamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeca e Pescoco Faculdade de Medicina Universidade Estadual Pualista Júlio Mesquita Filho - UNESP, Distrito Rubiao Junior, s/n, Botucatu, SP 18610-000
dc.description.affiliationDepartamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeca e Pescoco UNESP, Botucatu, SP
dc.description.affiliationDepartamento de Microbiologia Instituto de Biociências UNESP, Botucatu, SP
dc.description.affiliationDepartamento de Bioestatística Instituto de Biociências UNESP, Botucatu, SP
dc.description.affiliationUnespDepartamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeca e Pescoco Faculdade de Medicina Universidade Estadual Pualista Júlio Mesquita Filho - UNESP, Distrito Rubiao Junior, s/n, Botucatu, SP 18610-000
dc.description.affiliationUnespDepartamento de Oftalmologia Otorrinolaringologia e Cirurgia de Cabeca e Pescoco UNESP, Botucatu, SP
dc.description.affiliationUnespDepartamento de Microbiologia Instituto de Biociências UNESP, Botucatu, SP
dc.description.affiliationUnespDepartamento de Bioestatística Instituto de Biociências UNESP, Botucatu, SP
dc.format.extent73-77
dc.identifier.citationArquivos Brasileiros de Oftalmologia, v. 70, n. 1, p. 73-77, 2007.
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.scopus2-s2.0-34147136704
dc.identifier.urihttp://hdl.handle.net/11449/224885
dc.language.isopor
dc.relation.ispartofArquivos Brasileiros de Oftalmologia
dc.sourceScopus
dc.subjectAntimitotic agents
dc.subjectConjunctiva
dc.subjectFibroblasts/cytology
dc.subjectFluorouracil
dc.subjectMitomycin
dc.subjectPterygium
dc.subjectRecurrence
dc.titleExposição de fibroblastos da cápsula de Tenon normal de portadores de pterígio ao 5-fluorouracil e à mitomicina Cpt
dc.title.alternativeExposure of normal Tenon's capsule fibroblasts from pterygium to 5-fluorouracil and mitomycin Cen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentOftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço - FMBpt
unesp.departmentBioestatística - IBBpt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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Coleções

Botucatu - FMB - Faculdade de Medicina
Botucatu - IBB - Instituto de Biociências