Publicação:
Força de compressão e umidade no perfil de dissolução da hidroclorotiazida

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dc.contributor.authorDe Lima, Andréa Cristina [UNESP]
dc.contributor.authorMichelin, Daniele Carvalho [UNESP]
dc.contributor.authorSantos, Manoel Roberta Da Cruz
dc.contributor.authorPaganelli, Maria Ondina
dc.contributor.authorIgnácio, Rosa Fernanda
dc.contributor.authorChaud, Marco Vinícius
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFaculdade de Ciências da Saúde Curso de Farmácia
dc.date.accessioned2014-05-27T11:21:48Z
dc.date.available2014-05-27T11:21:48Z
dc.date.issued2006-01-01
dc.description.abstractThe aim of this work was to evaluate the influence of compression force and humidity in the dissolution profile of tablets formulation. As hidroclorotyiazide presents real problems of bioavailability, it was incorporate as standard drug in a formulation of tablets to study the mechanical resistance, time of disintegration and dissolution profile in function of humidity and compression force. The time of disintegration was not affected by the compression force, but it was influenced by humidity. The dissolution profile was altered by the compression force and for the humidity as well. Both factors can alter the bioavailability of drugs dispensed in the form of tablets.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos, Rodovia Araraquara - Jau, km 1, 14801-902, Araraquara - Sao Paulo
dc.description.affiliationUniversidade Metodista de Piracicaba (UNIMEP) Faculdade de Ciências da Saúde Curso de Farmácia, Rodovia do Acucar, km 157, 13400-911, Piracicaba - Sao Paulo
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas Departamento de Fármacos e Medicamentos, Rodovia Araraquara - Jau, km 1, 14801-902, Araraquara - Sao Paulo
dc.format.extent104-107
dc.identifierhttp://www.latamjpharm.org/trabajos/25/1/LAJOP_25_1_2_3_M2PJ125R5P.pdf
dc.identifier.citationActa Farmaceutica Bonaerense, v. 25, n. 1, p. 104-107, 2006.
dc.identifier.issn0326-2383
dc.identifier.scopus2-s2.0-33744470123
dc.identifier.urihttp://hdl.handle.net/11449/68750
dc.language.isopor
dc.relation.ispartofActa Farmaceutica Bonaerense
dc.relation.ispartofjcr0.401
dc.relation.ispartofsjr0,152
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDisintegration
dc.subjectDissolution profile
dc.subjectTablets
dc.subjecthydrochlorothiazide
dc.subjectcompressive strength
dc.subjectdissolution
dc.subjectdrug bioavailability
dc.subjectforce
dc.subjecthumidity
dc.subjecttablet formulation
dc.titleForça de compressão e umidade no perfil de dissolução da hidroclorotiazidapt
dc.title.alternativeCompression force and humidity in the dissolution profile of hidroclorotyazideen
dc.typeArtigo
dcterms.licensehttp://www.latamjpharm.org/
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas