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Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax

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dc.contributor.authorStorti-Melo, Luciane Moreno
dc.contributor.authorCosta, Daniela Reis da
dc.contributor.authorSouza-Neiras, Wanessa Christina
dc.contributor.authorCassiano, Gustavo Capatti [UNESP]
dc.contributor.authorD'Almeida Couto, Vanja Suely Calvosa
dc.contributor.authorPovoa, Marinete Marins
dc.contributor.authorSoares, Irene da Silva
dc.contributor.authorCarvalho, Luzia Helena de
dc.contributor.authorArevalo-Herrera, Myrian
dc.contributor.authorHerrera, Socrates
dc.contributor.authorBaptista Rossit, Andrea Regina
dc.contributor.authorCordeiro, Jose Antonio
dc.contributor.authorMattos, Luiz Carlos de
dc.contributor.authorMachado, Ricardo Luiz Dantas
dc.contributor.institutionUniversidade Federal de Sergipe (UFS)
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionUniversidade Federal do Triângulo Mineiro (UFTM)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNucleo Estadual Amapa CRDT
dc.contributor.institutionSecretaria Vigilancia Saude
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFundação Oswaldo Cruz
dc.contributor.institutionUniv Valle
dc.contributor.institutionUniversidade Federal Fluminense (UFF)
dc.date.accessioned2014-05-20T15:34:42Z
dc.date.available2014-05-20T15:34:42Z
dc.date.issued2012-02-01
dc.description.abstractWe evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HILA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the H1A-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Sergipe, Dept Biociencias, BR-49500000 Itabaiana, SE, Brazil
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP), Dept Doencas Dermatol Infecciosas & Parasitarias, Ctr Invest Microrganismos, BR-15090000 São Paulo, Brazil
dc.description.affiliationUniv Fed Triangulo Mineiro, Inst Ciencias Exatas Nat & Educ, BR-38025180 Uberaba, MC, Brazil
dc.description.affiliationUniv Estadual Paulista, BR-15054000 São Paulo, Brazil
dc.description.affiliationNucleo Estadual Amapa CRDT, Minist Saude, BR-68900430 Macapa, Amapa, Brazil
dc.description.affiliationSecretaria Vigilancia Saude, Inst Evandro Chagas, Lab Pesquisas Basicas Malaria, BR-6703000 Ananindeua, Para, Brazil
dc.description.affiliationUniv São Paulo, Fac Ciencias Farmaceut, BR-05508900 São Paulo, Brazil
dc.description.affiliationFundação Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Lab Malaria, BR-30190002 Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Valle, Fac Salud, Inst Inmunol, Cali, Colombia
dc.description.affiliationUniv Fed Fluminense, Inst Biomed, Dept Microbiol & Parasitol, BR-24210130 Rio de Janeiro, Brazil
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP), Dept Epidemiol, BR-15090000 São Paulo, Brazil
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP), Dept Biol Mol, Lab Imunohematol, BR-15090000 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, BR-15054000 São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCOLCIENCIAS
dc.description.sponsorshipMinistry of Social Protection
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseases (NIAID)
dc.description.sponsorshipIdFAPESP: 02/09546-1
dc.description.sponsorshipIdFAPESP: 06/09546-1
dc.description.sponsorshipIdCNPq: 302353/03-8
dc.description.sponsorshipIdCNPq: 410405/2006-0
dc.description.sponsorshipIdCOLCIENCIAS: 1106-04-16489)
dc.description.sponsorshipIdMinistry of Social Protection: 2304-04-19524
dc.description.sponsorshipIdMinistry of Social Protection: 253-2005
dc.description.sponsorshipIdNational Institute of Allergy and Infectious Diseases (NIAID): 49486/TMRC
dc.format.extent152-155
dc.identifierhttp://dx.doi.org/10.1016/j.actatropica.2011.10.009
dc.identifier.citationActa Tropica. Amsterdam: Elsevier B.V., v. 121, n. 2, p. 152-155, 2012.
dc.identifier.doi10.1016/j.actatropica.2011.10.009
dc.identifier.fileWOS000300132800014.pdf
dc.identifier.issn0001-706X
dc.identifier.urihttp://hdl.handle.net/11449/42629
dc.identifier.wosWOS:000300132800014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofActa Tropica
dc.relation.ispartofjcr2.509
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectPlasmodium vivaxen
dc.subjectHLA-DRB1en
dc.subjectAntibody responseen
dc.titleInfluence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivaxen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0002-8572-8177[13]
unesp.author.orcid0000-0002-6971-5974[4]
unesp.author.orcid0000-0002-0461-7521[11]
unesp.author.orcid0000-0002-8955-3204[14]
unesp.author.orcid0000-0002-3336-6856[7]

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