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Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer

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dc.contributor.authorStrakova, Andrea
dc.contributor.authorLeathlobhair, Maire Ni
dc.contributor.authorWang, Guo-Dong
dc.contributor.authorYin, Ting-Ting
dc.contributor.authorAirikkala-Otter, Ilona
dc.contributor.authorAllen, Janice L.
dc.contributor.authorAllum, Karen M.
dc.contributor.authorBansse-Issa, Leontine
dc.contributor.authorBisson, Jocelyn L.
dc.contributor.authorDomracheva, Artemio Castillo
dc.contributor.authorCastro, Karina F. de [UNESP]
dc.contributor.authorCorrigan, Anne M.
dc.contributor.authorCran, Hugh R.
dc.contributor.authorCrawford, Jane T.
dc.contributor.authorCutter, Stephen M.
dc.contributor.authorKeenan, Laura Delgadillo
dc.contributor.authorDonelan, Edward M.
dc.contributor.authorFaramade, Ibikunle A.
dc.contributor.authorReynoso, Erika Flores
dc.contributor.authorFotopoulou, Eleni
dc.contributor.authorFruean, Skye N.
dc.contributor.authorGallardo-Arrieta, Fanny
dc.contributor.authorGlebova, Olga
dc.contributor.authorHaefelin Manrique, Rodrigo F.
dc.contributor.authorHenriques, Joaquim J. G. P.
dc.contributor.authorIgnatenko, Natalia
dc.contributor.authorKoenig, Debbie
dc.contributor.authorLanza-Perea, Marta
dc.contributor.authorLobetti, Remo
dc.contributor.authorLopez Quintana, Adriana M.
dc.contributor.authorLosfelt, Thibault
dc.contributor.authorMarino, Gabriele
dc.contributor.authorMartincorena, Inigo
dc.contributor.authorCastaneda, Simon Martinez
dc.contributor.authorMartinez-Lopez, Mayra F.
dc.contributor.authorMeyer, Michael
dc.contributor.authorNakanwagi, Berne
dc.contributor.authorDe Nardi, Andrigo B. [UNESP]
dc.contributor.authorNeunzie, Winifred
dc.contributor.authorNixon, Sally J.
dc.contributor.authorOnsare, Marsden M.
dc.contributor.authorOrtega-Pacheco, Antonio
dc.contributor.authorPeleteiro, Maria C.
dc.contributor.authorPye, Ruth J.
dc.contributor.authorReece, John F.
dc.contributor.authorGutierrez, Jose Rojas
dc.contributor.authorSadia, Haleema
dc.contributor.authorSchmeling, Sheila K.
dc.contributor.authorShamanova, Olga
dc.contributor.authorSsuna, Richard K.
dc.contributor.authorSteenland-Smith, Audrey E.
dc.contributor.authorSvitich, Alla
dc.contributor.authorNgoka, Ismail Thoya
dc.contributor.authorVitalaru, Bogdan A.
dc.contributor.authorVos, Anna P. de
dc.contributor.authorVos, Johan P. de
dc.contributor.authorWalkinton, Oliver
dc.contributor.authorWedge, David C.
dc.contributor.authorWehrle-Martinez, Alvaro S.
dc.contributor.authorvan der Wel, Mirjam G.
dc.contributor.authorWiddowson, Sophie A. E.
dc.contributor.authorMurchison, Elizabeth P.
dc.contributor.institutionUniv Cambridge
dc.contributor.institutionChinese Acad Sci
dc.contributor.institutionInt Training Ctr
dc.contributor.institutionAnim Management Rural & Remote Indigenous Commun
dc.contributor.institutionWorld Vets
dc.contributor.institutionStichting Dierenbescherming Suriname
dc.contributor.institutionUniv Panama
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSt Georges Univ
dc.contributor.institutionNakuru Dist Vet Scheme Ltd
dc.contributor.institutionAnim Med Ctr
dc.contributor.institutionVet Clin Sr Dogs
dc.contributor.institutionNatl Inst Vet Res
dc.contributor.institutionInt Fund Anim Welf
dc.contributor.institutionIntermunicipal Stray Anim Care Ctr
dc.contributor.institutionAnim Protect Soc Samoa
dc.contributor.institutionUniv Zulia
dc.contributor.institutionVet Clin BIOCONTROL
dc.contributor.institutionVet Clin El Roble
dc.contributor.institutionCtr Vet Berna
dc.contributor.institutionVet Clin Zoovetservis
dc.contributor.institutionBryanston Vet Hosp
dc.contributor.institutionVet Clin Lopez Quintana
dc.contributor.institutionClin Vet Grand Fond
dc.contributor.institutionUniv Messina
dc.contributor.institutionWellcome Trust Sanger Inst
dc.contributor.institutionUniv Autonoma Estado Mexico
dc.contributor.institutionAmer Univ
dc.contributor.institutionTouray & Meyer Vet Clin
dc.contributor.institutionKampala Vet Surg
dc.contributor.institutionVets Borders
dc.contributor.institutionAniworld Vet Clin
dc.contributor.institutionAutonomous Univ Yucatan
dc.contributor.institutionUniv Lisbon
dc.contributor.institutionHelp Suffering
dc.contributor.institutionVet Clin Dr Jose Rojas
dc.contributor.institutionUniv Vet & Anim Sci
dc.contributor.institutionCorozal Vet Clin
dc.contributor.institutionVet Clin Vetmaster
dc.contributor.institutionLilongwe Soc Protect & Care Anim
dc.contributor.institutionState Hosp Vet Med
dc.contributor.institutionKenya Soc Protect & Care Anim
dc.contributor.institutionFac Vet Med
dc.contributor.institutionLadybrand Anim Clin
dc.contributor.institutionVet Oncol Referral Ctr Ottenhorst
dc.contributor.institutionNatl Univ Asunc
dc.contributor.institutionAnim Anti Cruelty League
dc.date.accessioned2018-11-26T15:29:55Z
dc.date.available2018-11-26T15:29:55Z
dc.date.issued2016-05-17
dc.description.abstractCanine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.en
dc.description.affiliationUniv Cambridge, Dept Vet Med, Cambridge, England
dc.description.affiliationChinese Acad Sci, Kunming Inst Zool, Yunnan Lab Mol Biol Domest Anim, State Key Lab Genet Resources & Evolut, Kunming, Peoples R China
dc.description.affiliationInt Training Ctr, Worldwide Vet Serv, Aruvankadu, India
dc.description.affiliationAnim Management Rural & Remote Indigenous Commun, Darwin, NT, Australia
dc.description.affiliationWorld Vets, Fargo, ND USA
dc.description.affiliationStichting Dierenbescherming Suriname, Paramaribo, Surinam
dc.description.affiliationUniv Panama, Corozal Vet Hosp, Panama City, Panama
dc.description.affiliationSao Paulo State Univ, Dept Clin & Vet Surg, Sao Paulo, Brazil
dc.description.affiliationSt Georges Univ, True Blue, Grenada
dc.description.affiliationNakuru Dist Vet Scheme Ltd, Nakuru, Kenya
dc.description.affiliationAnim Med Ctr, Belize City, Belize
dc.description.affiliationVet Clin Sr Dogs, Guadalajara, Mexico
dc.description.affiliationNatl Inst Vet Res, Vom, Nigeria
dc.description.affiliationInt Fund Anim Welf, Quintana Roo, Mexico
dc.description.affiliationIntermunicipal Stray Anim Care Ctr, Perama, Greece
dc.description.affiliationAnim Protect Soc Samoa, Apia, Samoa
dc.description.affiliationUniv Zulia, Fac Vet Sci, Maracaibo, Venezuela
dc.description.affiliationVet Clin BIOCONTROL, Moscow, Russia
dc.description.affiliationVet Clin El Roble, Santiago, Chile
dc.description.affiliationCtr Vet Berna, OnevetGrp, Lisbon, Portugal
dc.description.affiliationVet Clin Zoovetservis, Kiev, Ukraine
dc.description.affiliationBryanston Vet Hosp, Bryanston, South Africa
dc.description.affiliationVet Clin Lopez Quintana, Maldonado, Uruguay
dc.description.affiliationClin Vet Grand Fond, St Gilles Les Bains, France
dc.description.affiliationUniv Messina, Dept Vet Sci, Messina, Italy
dc.description.affiliationWellcome Trust Sanger Inst, Hinxton, England
dc.description.affiliationUniv Autonoma Estado Mexico, Fac Med Vet & Zootecnia, Toluca, Mexico
dc.description.affiliationAmer Univ, Sch Vet Med, Quito, Ecuador
dc.description.affiliationTouray & Meyer Vet Clin, Serrekunda, Gambia
dc.description.affiliationKampala Vet Surg, Kampala, Uganda
dc.description.affiliationVets Borders, The Rocks, Australia
dc.description.affiliationAniworld Vet Clin, Kisumu, Kenya
dc.description.affiliationAutonomous Univ Yucatan, Fac Vet Med, Merida, Mexico
dc.description.affiliationUniv Lisbon, Fac Vet Med, Interdisciplinary Ctr Res Anim Hlth, P-1699 Lisbon, Portugal
dc.description.affiliationHelp Suffering, Jaipur, Rajasthan, India
dc.description.affiliationVet Clin Dr Jose Rojas, Los Andes, Chile
dc.description.affiliationUniv Vet & Anim Sci, Lahore, Pakistan
dc.description.affiliationCorozal Vet Clin, Corozal Town, Belize
dc.description.affiliationVet Clin Vetmaster, Ramenskoye, Russia
dc.description.affiliationLilongwe Soc Protect & Care Anim, Lilongwe, Malawi
dc.description.affiliationState Hosp Vet Med, Dniprodzerzhynsk, Ukraine
dc.description.affiliationKenya Soc Protect & Care Anim, Nairobi, Kenya
dc.description.affiliationFac Vet Med, Dept Clin Sci, Bucharest, Romania
dc.description.affiliationLadybrand Anim Clin, Ladybrand, South Africa
dc.description.affiliationVet Oncol Referral Ctr Ottenhorst, Terneuzen, Netherlands
dc.description.affiliationNatl Univ Asunc, Fac Vet Sci, San Lorenzo, Paraguay
dc.description.affiliationAnim Anti Cruelty League, Port Elizabeth, South Africa
dc.description.affiliationUnespSao Paulo State Univ, Dept Clin & Vet Surg, Sao Paulo, Brazil
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipLeverhulme Trust
dc.description.sponsorshipRoyal Society
dc.description.sponsorshipIdWellcome Trust: 102942/Z/13/A
dc.description.sponsorshipIdRoyal Society: RG130615
dc.format.extent25
dc.identifierhttp://dx.doi.org/10.7554/eLife.14552
dc.identifier.citationElife. Cambridge: Elife Sciences Publications Ltd, v. 5, 25 p., 2016.
dc.identifier.doi10.7554/eLife.14552
dc.identifier.fileWOS000376922000001.pdf
dc.identifier.issn2050-084X
dc.identifier.urihttp://hdl.handle.net/11449/158902
dc.identifier.wosWOS:000376922000001
dc.language.isoeng
dc.publisherElife Sciences Publications Ltd
dc.relation.ispartofElife
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleMitochondrial genetic diversity, selection and recombination in a canine transmissible canceren
dc.typeArtigo
dcterms.rightsHolderElife Sciences Publications Ltd
dspace.entity.typePublication
unesp.author.lattes5256503293611165[38]
unesp.author.orcid0000-0001-6463-2144[38]

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