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Mean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant women

dc.contributor.authorMayrink, Jussara
dc.contributor.authorSouza, Renato T.
dc.contributor.authorFeitosa, Francisco E.
dc.contributor.authorRocha Filho, Edilberto A.
dc.contributor.authorLeite, Débora F.
dc.contributor.authorVettorazzi, Janete
dc.contributor.authorCalderon, Iracema M. [UNESP]
dc.contributor.authorCosta, Maria L.
dc.contributor.authorKenny, Louise
dc.contributor.authorBaker, Philip
dc.contributor.authorCecatti, Jose G.
dc.contributor.authorParpinelli, Mary A.
dc.contributor.authorFernandes, Karayna G.
dc.contributor.authorGuida, José P.
dc.contributor.authorSantana, Danielly
dc.contributor.authorGalvao, Rafael B. F.
dc.contributor.authorCassettari, Bianca F.
dc.contributor.authorPfitscher, Lucia
dc.contributor.authorDe Feitosa, Daisy Lucena
dc.contributor.authorDe Melo Ferreira Júnior, Elias
dc.contributor.authorAnacleto, Danilo
dc.contributor.authorZotareli, Vilma
dc.contributor.authorSilva, Marcia Alice
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionFederal University of Ceará
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionFederal University of RS
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Leicester
dc.contributor.institutionUniversity of Liverpool
dc.date.accessioned2020-12-12T01:48:20Z
dc.date.available2020-12-12T01:48:20Z
dc.date.issued2019-12-03
dc.description.abstractBackground: Prediction of preeclampsia is a challenge to overcome. The vast majority of prospective studies in large general obstetric populations have failed in the purpose of obtain a useful and effective model of prediction, sometimes based on complex tools unavaible in areas where the incidence of preeclampsia is the highest. The goal of this study was to assess mean arterial blood pressure (MAP) levels at 19-21, 27-29 and 37-39 weeks of gestation and performance of screening by MAP for the prediction of preeclampsia in a Brazilian cohort of healthy nulliparous pregnant women. Methods: This was a cohort approach to a secondary analysis of the Preterm SAMBA study. Mean arterial blood pressure was evaluated at three different time periods during pregnancy. Groups with early-onset preeclampsia, late-onset preeclampsia and normotension were compared. Increments in mean arterial blood pressure between 20 and 27 weeks and 20 and 37 weeks of gestation were also calculated for the three groups studied. The accuracy of mean arterial blood pressure in the prediction of preeclampsia was determined by ROC curves. Results: Of the 1373 participants enrolled, complete data were available for 1165. The incidence of preeclampsia was 7.5%. Women with early-onset preeclampsia had higher mean arterial blood pressure levels at 20 weeks of gestation, compared to the normotensive group. Women with late-onset preeclampsia had higher mean arterial blood pressure levels at 37 weeks of gestation, than the normotensive groups and higher increases in this marker between 20 and 37 weeks of gestation. Based on ROC curves, the predictive performance of mean arterial blood pressure was higher at 37 weeks of gestation, with an area under the curve of 0.771. Conclusion: As an isolated marker for the prediction of preeclampsia, the performance of mean arterial blood pressure was low in a healthy nulliparous pregnant women group. Considering that early-onset preeclampsia cases had higher mean arterial blood pressure levels at 20 weeks of gestation, future studies with larger cohorts that combine multiple markers are needed for the development of a preeclampsia prediction model.en
dc.description.affiliationDepartment of Obstetrics and Gynecology University of Campinas (UNICAMP) School of Medical Sciences, Rua Alexander Fleming, 101
dc.description.affiliationMEAC Maternity Hospital Federal University of Ceará
dc.description.affiliationDepartment of Maternal and Child Health Maternity Hospital Federal University of Pernambuco
dc.description.affiliationDepartment of Obstetrics and Gynecology Maternity Hospital Federal University of RS
dc.description.affiliationDepartment of Obstetrics and Gynecology Botucatu Medical School Unesp
dc.description.affiliationCollege of Life Sciences University of Leicester
dc.description.affiliationFaculty of Health and Life Sciences Department of Women's and Children's Health Institute of Translational Medicine University of Liverpool
dc.description.affiliationUnespDepartment of Obstetrics and Gynecology Botucatu Medical School Unesp
dc.identifierhttp://dx.doi.org/10.1186/s12884-019-2580-4
dc.identifier.citationBMC Pregnancy and Childbirth, v. 19, n. 1, 2019.
dc.identifier.doi10.1186/s12884-019-2580-4
dc.identifier.issn1471-2393
dc.identifier.scopus2-s2.0-85075929304
dc.identifier.urihttp://hdl.handle.net/11449/199750
dc.language.isoeng
dc.relation.ispartofBMC Pregnancy and Childbirth
dc.sourceScopus
dc.subjectBlood pressure
dc.subjectHypertension
dc.subjectPreeclampsia
dc.subjectPrenatal screening
dc.subjectSecond trimester
dc.subjectThird trimester
dc.titleMean arterial blood pressure: Potential predictive tool for preeclampsia in a cohort of healthy nulliparous pregnant womenen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0003-1285-8445[11]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentGinecologia e Obstetrícia - FMBpt

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