Publication: Analysis of a sub-optimal scheme of drug dosage in the AIDS treatment
Loading...
Date
Advisor
Coadvisor
Graduate program
Undergraduate course
Journal Title
Journal ISSN
Volume Title
Publisher
Type
Work presented at event
Access right
Acesso aberto
Abstract
Here the results for CD4+T cells count and the viral load obtained from HIV sero-positive patients are compared with results from numerical simulations by computer. Also, the standard scheme of administration of drugs anti HIV (HAART schemes) which uses constant doses is compared with an alternative sub-optimal teatment scheme which uses variable drug dosage according to the evolution of a quantitative measure of the side effects. The quantitative analysis done here shows that it is possible to obtain, using the alternative scheme, the same performance of actual data but using variable dosage and having fewer side effects. Optimal control theory is used to solve and also to provide a prognosis related to the strategies for control of viraemia.
Description
Keywords
AIDS, Direct method, Optimization, Treatment, Computer simulation, Drug dosage, Patient treatment, Problem solving, Viruses, Sub-optimal scheme, Control theory
Language
English
Citation
Proceedings of the American Control Conference, v. 2, p. 1188-1193.
