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Analysis of a sub-optimal scheme of drug dosage in the AIDS treatment

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dc.contributor.authorFelippe de Souza, J. A M
dc.contributor.authorCaetano, M. A L [UNESP]
dc.contributor.authorYoneyama, Takashi
dc.contributor.institutionUniversidade da Beira Interior
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst. Tecn. de Aeronáutica
dc.date.accessioned2014-05-27T11:20:56Z
dc.date.available2014-05-27T11:20:56Z
dc.date.issued2003-11-07
dc.description.abstractHere the results for CD4+T cells count and the viral load obtained from HIV sero-positive patients are compared with results from numerical simulations by computer. Also, the standard scheme of administration of drugs anti HIV (HAART schemes) which uses constant doses is compared with an alternative sub-optimal teatment scheme which uses variable drug dosage according to the evolution of a quantitative measure of the side effects. The quantitative analysis done here shows that it is possible to obtain, using the alternative scheme, the same performance of actual data but using variable dosage and having fewer side effects. Optimal control theory is used to solve and also to provide a prognosis related to the strategies for control of viraemia.en
dc.description.affiliationUniversidade da Beira Interior, Covilhã
dc.description.affiliationUniversidade Estadual Paulista IGCE, Rio Claro
dc.description.affiliationInst. Tecn. de Aeronáutica, São José dos Campos
dc.description.affiliationUnespUniversidade Estadual Paulista IGCE, Rio Claro
dc.format.extent1188-1193
dc.identifierhttp://dx.doi.org/10.1109/ACC.2003.1239749
dc.identifier.citationProceedings of the American Control Conference, v. 2, p. 1188-1193.
dc.identifier.doi10.1109/ACC.2003.1239749
dc.identifier.issn0743-1619
dc.identifier.scopus2-s2.0-0142169391
dc.identifier.urihttp://hdl.handle.net/11449/67471
dc.language.isoeng
dc.relation.ispartofProceedings of the American Control Conference
dc.relation.ispartofsjr0,500
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectAIDS
dc.subjectDirect method
dc.subjectOptimization
dc.subjectTreatment
dc.subjectComputer simulation
dc.subjectDrug dosage
dc.subjectPatient treatment
dc.subjectProblem solving
dc.subjectViruses
dc.subjectSub-optimal scheme
dc.subjectControl theory
dc.titleAnalysis of a sub-optimal scheme of drug dosage in the AIDS treatmenten
dc.typeTrabalho apresentado em eventopt
dcterms.licensehttp://www.ieee.org/publications_standards/publications/rights/rights_policies.html
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Geociências e Ciências Exatas, Rio Claropt

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Rio Claro - IGCE - Instituto de Geociências e Ciências Exatas