Logo do repositório
 

Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection

dc.contributor.authorCrispim, J. C. O.
dc.contributor.authorDuarte, R. A. [UNESP]
dc.contributor.authorSoares, Christiane Pienna [UNESP]
dc.contributor.authorCosta, R.
dc.contributor.authorSilva, J. S.
dc.contributor.authorMendes-Junior, C. T.
dc.contributor.authorWastowski, I. J.
dc.contributor.authorFaggioni, L. P.
dc.contributor.authorSaber, L. T.
dc.contributor.authorDonadi, E. A.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.date.accessioned2014-05-20T15:33:02Z
dc.date.available2014-05-20T15:33:02Z
dc.date.issued2008-02-01
dc.description.abstractHLA-G is a non-classic Human Leukocyte Antigen (HLA-G) Class I of low polymorphism and restricted tissue distribution that displays tolerogenic functions. In heart transplantation and in combined liver/renal allograft transplantation, the expression of HLA-G has been associated with a lower incidence of acute graft rejection episodes and absence of chronic dysfunction. Since the expression of HLA-G in renal biopsies has been investigated only in few patients who received a combined kidney and liver transplant, in this study we performed a cross-sectional study, systematically comparing the expression of HLA-G in post-transplanted renal grafts, stratifying patients according to the presence or absence of rejection.Patients and Methods: Seventy-three renal specimens (10 with acute rejection and 13 with chronic allograft nephropathy, and 50 with no signs of rejection) were immunohistochemically evaluated for HLA-G expression.Results: In the group as a whole, HLA-G molecules were detected in 40 cases (54.8%). Among specimens that presented HLA-G expression, 2 out of 40 (5%) exhibited acute rejection, 2 (5%) exhibited chronic allograft nephropathy, and the remaining 36 (90%) exhibited no signs of rejection. The comparison between patients with rejection and those without rejection showed that the expression of HLA-G was significantly increased in specimens exhibiting no signs of rejection (p<0.0001). Considering only patients with acute rejection, 8 out of 10 patients showed no HLA-G expression in their kidney biopsies when compared to patients exhibiting no signs of rejection and absence of HLA-G was observed in 14 out of 50 (p=0.0032). Similarly, considering only patients with chronic allograft nephropathy, absence of HLA-G expression was observed in I I out of 13 specimens, whereas in patients without rejection absence of HLA-G was observed in 14 out of 50 (p=0.003). Therapy with tacrolimus was significantly associated with the expression of HLA-G and a better graft prognosis. Conclusions: Our results suggest that HLA-G expression in the kidney allograft and the use of tacrolimus are associated with a lower frequency of acute renal rejection and chronic allograft nephropathy. (c) 2007 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Fac Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo State, UNESP, Sch Pharmaceut Sci, Dept Clin Anal, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, FMRP, Div Clin Immunol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, FMRP, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Carlos (UFSCar), Dept Med, Ctr Biol & Hlth Sci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, FMRP, Renal Transplant Unity, São Paulo, Brazil
dc.description.affiliationUnespUniv São Paulo State, UNESP, Sch Pharmaceut Sci, Dept Clin Anal, São Paulo, Brazil
dc.format.extent361-367
dc.identifierhttp://dx.doi.org/10.1016/j.trim.2007.10.010
dc.identifier.citationTransplant Immunology. Amsterdam: Elsevier B.V., v. 18, n. 4, p. 361-367, 2008.
dc.identifier.doi10.1016/j.trim.2007.10.010
dc.identifier.issn0966-3274
dc.identifier.lattes1768025290373669
dc.identifier.orcid0000-0003-1740-7360
dc.identifier.urihttp://hdl.handle.net/11449/41781
dc.identifier.wosWOS:000252572000011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTransplant Immunology
dc.relation.ispartofjcr1.655
dc.relation.ispartofsjr0,620
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectkidney allograften
dc.subjectHLA-Gen
dc.subjectrejectionen
dc.titleHuman leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejectionen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes1768025290373669[3]
unesp.author.orcid0000-0002-9457-9601[10]
unesp.author.orcid0000-0002-7337-1203[6]
unesp.author.orcid0000-0001-5441-4186[7]
unesp.author.orcid0000-0003-1740-7360[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt

Arquivos

Licença do pacote

Agora exibindo 1 - 2 de 2
Carregando...
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Carregando...
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição: