Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection
dc.contributor.author | Crispim, J. C. O. | |
dc.contributor.author | Duarte, R. A. [UNESP] | |
dc.contributor.author | Soares, Christiane Pienna [UNESP] | |
dc.contributor.author | Costa, R. | |
dc.contributor.author | Silva, J. S. | |
dc.contributor.author | Mendes-Junior, C. T. | |
dc.contributor.author | Wastowski, I. J. | |
dc.contributor.author | Faggioni, L. P. | |
dc.contributor.author | Saber, L. T. | |
dc.contributor.author | Donadi, E. A. | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade Federal de São Carlos (UFSCar) | |
dc.date.accessioned | 2014-05-20T15:33:02Z | |
dc.date.available | 2014-05-20T15:33:02Z | |
dc.date.issued | 2008-02-01 | |
dc.description.abstract | HLA-G is a non-classic Human Leukocyte Antigen (HLA-G) Class I of low polymorphism and restricted tissue distribution that displays tolerogenic functions. In heart transplantation and in combined liver/renal allograft transplantation, the expression of HLA-G has been associated with a lower incidence of acute graft rejection episodes and absence of chronic dysfunction. Since the expression of HLA-G in renal biopsies has been investigated only in few patients who received a combined kidney and liver transplant, in this study we performed a cross-sectional study, systematically comparing the expression of HLA-G in post-transplanted renal grafts, stratifying patients according to the presence or absence of rejection.Patients and Methods: Seventy-three renal specimens (10 with acute rejection and 13 with chronic allograft nephropathy, and 50 with no signs of rejection) were immunohistochemically evaluated for HLA-G expression.Results: In the group as a whole, HLA-G molecules were detected in 40 cases (54.8%). Among specimens that presented HLA-G expression, 2 out of 40 (5%) exhibited acute rejection, 2 (5%) exhibited chronic allograft nephropathy, and the remaining 36 (90%) exhibited no signs of rejection. The comparison between patients with rejection and those without rejection showed that the expression of HLA-G was significantly increased in specimens exhibiting no signs of rejection (p<0.0001). Considering only patients with acute rejection, 8 out of 10 patients showed no HLA-G expression in their kidney biopsies when compared to patients exhibiting no signs of rejection and absence of HLA-G was observed in 14 out of 50 (p=0.0032). Similarly, considering only patients with chronic allograft nephropathy, absence of HLA-G expression was observed in I I out of 13 specimens, whereas in patients without rejection absence of HLA-G was observed in 14 out of 50 (p=0.003). Therapy with tacrolimus was significantly associated with the expression of HLA-G and a better graft prognosis. Conclusions: Our results suggest that HLA-G expression in the kidney allograft and the use of tacrolimus are associated with a lower frequency of acute renal rejection and chronic allograft nephropathy. (c) 2007 Elsevier B.V. All rights reserved. | en |
dc.description.affiliation | Univ São Paulo, Fac Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, SP, Brazil | |
dc.description.affiliation | Univ São Paulo State, UNESP, Sch Pharmaceut Sci, Dept Clin Anal, São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, FMRP, Div Clin Immunol, São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, FMRP, Dept Pathol, São Paulo, Brazil | |
dc.description.affiliation | Universidade Federal de São Carlos (UFSCar), Dept Med, Ctr Biol & Hlth Sci, São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, FMRP, Renal Transplant Unity, São Paulo, Brazil | |
dc.description.affiliationUnesp | Univ São Paulo State, UNESP, Sch Pharmaceut Sci, Dept Clin Anal, São Paulo, Brazil | |
dc.format.extent | 361-367 | |
dc.identifier | http://dx.doi.org/10.1016/j.trim.2007.10.010 | |
dc.identifier.citation | Transplant Immunology. Amsterdam: Elsevier B.V., v. 18, n. 4, p. 361-367, 2008. | |
dc.identifier.doi | 10.1016/j.trim.2007.10.010 | |
dc.identifier.issn | 0966-3274 | |
dc.identifier.lattes | 1768025290373669 | |
dc.identifier.orcid | 0000-0003-1740-7360 | |
dc.identifier.uri | http://hdl.handle.net/11449/41781 | |
dc.identifier.wos | WOS:000252572000011 | |
dc.language.iso | eng | |
dc.publisher | Elsevier B.V. | |
dc.relation.ispartof | Transplant Immunology | |
dc.relation.ispartofjcr | 1.655 | |
dc.relation.ispartofsjr | 0,620 | |
dc.rights.accessRights | Acesso restrito | pt |
dc.source | Web of Science | |
dc.subject | kidney allograft | en |
dc.subject | HLA-G | en |
dc.subject | rejection | en |
dc.title | Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection | en |
dc.type | Artigo | pt |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dcterms.rightsHolder | Elsevier B.V. | |
dspace.entity.type | Publication | |
relation.isDepartmentOfPublication | a83d26d6-5383-42e4-bb3c-2678a6ddc144 | |
relation.isDepartmentOfPublication.latestForDiscovery | a83d26d6-5383-42e4-bb3c-2678a6ddc144 | |
relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
unesp.author.lattes | 1768025290373669[3] | |
unesp.author.orcid | 0000-0002-9457-9601[10] | |
unesp.author.orcid | 0000-0002-7337-1203[6] | |
unesp.author.orcid | 0000-0001-5441-4186[7] | |
unesp.author.orcid | 0000-0003-1740-7360[3] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Análises Clínicas - FCF | pt |
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