Publicação: Propolis anti-inflammatory effects on MAGE-1 and retinoic acid-treated dendritic cells and on Th1 and T regulatory cells
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Cevap-sao Paulo State Univ-unesp
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Background: Propolis exhibits huge potential in the pharmaceutical industry. In the present study, its effects were investigated on dendritic cells (DCs) stimulated with a tumor antigen (MAGE-1) and retinoic acid (RA) and on T lymphocytes to observe a possible differential activation of T lymphocytes, driving preferentially to Th1 or Treg cells.Methods: Cell viability, lymphocyte proliferation, gene expression (T-bet and FoxP3), and cytokine production by DCs (TNF-alpha, IL-10, IL-6 and IL-1 beta) and lymphocytes (IFN-gamma and TGF-beta) were analyzed.Results: MAGE-1 and RA alone or in combination with propolis inhibited TNF-alpha production and induced a higher lymphoproliferation compared to control, while MAGE-1 + propolis induced IL-6 production. Propolis in combination with RA induced FoxP3 expression. MAGE-1 induced IFN-gamma production while propolis inhibited it, returning to basal levels. RA inhibited TGF-beta production, what was counteracted by propolis.Conclusion: Propolis affected immunological parameters inhibiting pro-inflammatory cytokines and favoring the regulatory profile, opening perspectives for the control of inflammatory conditions.
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Dendritic cells, T CD4+cells, MAGE-1, Retinoic acid, Propolis, Immunomodulation
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Inglês
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Journal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-sao Paulo State Univ - Unesp, v. 29, 12 p., 2023.
