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Rabies infection and specific effect of vaccination in mice selected for high and low immunobiological parameters

dc.contributor.authorQueiroz-da-Silva, L.H. [UNESP]
dc.contributor.authorDe-Franco, M.
dc.contributor.authorSant'Anna, O.A
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Butantan
dc.date.accessioned2014-05-20T15:11:29Z
dc.date.available2014-05-20T15:11:29Z
dc.date.issued1997-11-01
dc.description.abstractInnate and acquired resistance to rabies infection was investigated in mice genetically selected for high (H) or low (L) antibody responsiveness from selections I, III and IV and in mice selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction. These mouse lines were infected intramuscularly with different virus dilutions and the LD50 was determined. The HIII and HIV mouse lines were more susceptible than the LIII and LIV lines and the HI line showed a discrete but higher resistance than the LI line. Analysis of the interline (H x L) F1 hybrids from selections III and IV indicated different dominance effects on the resistant and susceptible phenotypes when the route of vaccination was changed. No differences were observed between the AIRmax and AIRmin mice, suggesting that inflammation plays a minor role in the resistance to rabies virus. The comparison of LD50 in mice vaccinated by distinct routes showed that the highest interline difference occurred after intramuscular vaccination (250-fold between H and L and 800-fold between F1 and L). These results indicate that different mechanisms may participate in acquired antirabies resistanceen
dc.description.affiliationUniversidade Estadual Paulista
dc.description.affiliationInstituto Butantan
dc.description.affiliationUnespUniversidade Estadual Paulista
dc.format.extent1309-1313
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1997001100008
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 30, n. 11, p. 1309-1313, 1997.
dc.identifier.doi10.1590/S0100-879X1997001100008
dc.identifier.fileS0100-879X1997001100008.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1997001100008
dc.identifier.urihttp://hdl.handle.net/11449/28052
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.relation.ispartofjcr1.492
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectrabiesen
dc.subjectantibodyen
dc.subjectvaccinationen
dc.subjecthigh and low antibody responder miceen
dc.titleRabies infection and specific effect of vaccination in mice selected for high and low immunobiological parametersen
dc.typeArtigo
dspace.entity.typePublication

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