Logo do repositório

Fibrous-biocomposites scaffold of natural rubber with bioactive glass–ceramic particles obtained by solution blowing spinning

dc.contributor.authorLima, Luiz Rogério Monteiro [UNESP]
dc.contributor.authorVilches, José Luiz [UNESP]
dc.contributor.authorCaetano, Guilherme Ferreira
dc.contributor.authorSilva, Lais Dantas
dc.contributor.authorSoares, Viviane Oliveira
dc.contributor.authordos Santos, Renivaldo José [UNESP]
dc.contributor.authorSanches, Alex Otávio [UNESP]
dc.contributor.authorMalmonge, José Antônio [UNESP]
dc.contributor.authorYarin, Alexander L.
dc.contributor.authorSilva, Michael Jones [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFHO
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFederal Institute of Maranhão - IFMA
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.contributor.institutionUniversity of Illinois at Chicago (UIC)
dc.date.accessioned2025-04-29T20:02:45Z
dc.date.issued2025-03-10
dc.description.abstractBioactive glass-ceramics (BGs) are widely used in clinical applications due to their excellent biodynamic and biological properties, though their low mechanical strength limits their use in load-bearing contexts. This study aimed to develop fibrous biocomposite scaffolds based on natural rubber (NR) reinforced with BG particles, such as biosilicato (BioS) and 45S5-K (BL0), to improve tensile strength, biocompatibility, and bioactivity for biomedical applications, such as tissue engineering. Morphological, tensile, thermal, and biological tests were conducted to evaluate the impact of BG particles on the NR fibrous matrix. TG/DTG analysis revealed similar decomposition profiles for NR/BioS and NR/BL0 biocomposites compared to NR mats, with primary degradation occurring in the 290–450°C range. Tensile tests demonstrated that the addition of 30 mass% BioS or BL0 enhanced the ultimate tensile strength (σbreak) of the NR matrix from 1.44 ± 0.08 to 3.38 ± 1.31 MPa (NR/BioS) and 1.97 ± 0.53 MPa (NR/BL0). The Cole–Cole plot indicated system heterogeneity and strong NR-BG particle interactions. Cytotoxicity tests revealed over 70% MSC viability for NR, NR/BioS, and NR/BL0 biocomposites, meeting ISO 10993-5:2009 standards. These findings suggest that incorporating BioS and BL0 enhances the mechanical and biological properties of NR-based scaffolds, making them suitable for biomedical applications, such as bone regeneration.en
dc.description.affiliationDepartment of Physics and Chemistry School of Engineering São Paulo State University (UNESP), São Paulo
dc.description.affiliationGraduate Program in Biomedical Sciences University Center of Hermínio Ometto Foundation FHO, São Paulo
dc.description.affiliationDivision of Dermatology Department of Internal Medicine Ribeirão Preto Medical School University of São Paulo, São Paulo
dc.description.affiliationPostgraduate Program in Materials Engineering Federal Institute of Maranhão - IFMA, São Luis
dc.description.affiliationDepartment of Sciences Regional Campus of Goioerê State University of Maringá (UEM), Paraná
dc.description.affiliationDepartment of Engineering School of Engineering and Science São Paulo State University (UNESP), São Paulo
dc.description.affiliationDepartment of Mechanical and Industrial Engineering University of Illinois at Chicago (UIC)
dc.description.affiliationUnespDepartment of Physics and Chemistry School of Engineering São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespDepartment of Engineering School of Engineering and Science São Paulo State University (UNESP), São Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2021/1051-5
dc.identifierhttp://dx.doi.org/10.1002/app.56448
dc.identifier.citationJournal of Applied Polymer Science, v. 142, n. 10, 2025.
dc.identifier.doi10.1002/app.56448
dc.identifier.issn1097-4628
dc.identifier.issn0021-8995
dc.identifier.scopus2-s2.0-85208419168
dc.identifier.urihttps://hdl.handle.net/11449/305316
dc.language.isoeng
dc.relation.ispartofJournal of Applied Polymer Science
dc.sourceScopus
dc.subjectbiomaterials
dc.subjectbiomedical applications
dc.subjectbiopolymers and renewable polymers
dc.subjectcomposites
dc.subjectrubber
dc.titleFibrous-biocomposites scaffold of natural rubber with bioactive glass–ceramic particles obtained by solution blowing spinningen
dc.typeArtigopt
dspace.entity.typePublication
unesp.author.orcid0000-0001-8032-2525[9]
unesp.author.orcid0000-0002-2971-1696[10]

Arquivos

Coleções