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Crystallization and preliminary X-ray diffraction analysis of importin-alpha acomplexed with NLS peptidomimetics

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dc.contributor.authorFontes, MRM
dc.contributor.authorTeh, T.
dc.contributor.authorRiell, R. D.
dc.contributor.authorPark, S. B.
dc.contributor.authorStandaert, R. E.
dc.contributor.authorKobe, B.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Queensland
dc.contributor.institutionUniv Illinois
dc.contributor.institutionSeoul Natl Univ
dc.date.accessioned2014-05-20T13:49:18Z
dc.date.available2014-05-20T13:49:18Z
dc.date.issued2005-06-15
dc.description.abstractImportin-alpha is the nuclear import receptor that recognizes cargo proteins with nuclear localization sequences (NLSs). Tile study of NLS peptidomimetics can provide a better understanding of the requirements for the molecular recognition of cargo proteins by importin-alpha, and potentially engender a large number of applications in medicine. Importin-a was crystallized with a set of six NLS peptidomimetics, and X-ray diffraction data were collected in the range 2.1-2.5 angstrom resolution. Preliminary electron density calculations show that the ligands are present in the crystals. (c) 2005 Elsevier B.V All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Dept Fis & Biofis, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Queensland, Dept Biochem & Mol Biol, Inst Mol Biosci, ARC Special Res Ctr Funct & Appl Genom, Brisbane, Qld 4072, Australia
dc.description.affiliationUniv Queensland, Cooperat Res Ctr Chron Inflammatory Dis, Brisbane, Qld 4072, Australia
dc.description.affiliationUniv Illinois, Dept Chem, Chicago, IL USA
dc.description.affiliationSeoul Natl Univ, Sch Chem, Seoul 151742, South Korea
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Dept Fis & Biofis, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil
dc.format.extent9-13
dc.identifierhttp://dx.doi.org/10.1016/j.bbapap.2005.03.014
dc.identifier.citationBiochimica Et Biophysica Acta-proteins and Proteomics. Amsterdam: Elsevier B.V., v. 1750, n. 1, p. 9-13, 2005.
dc.identifier.doi10.1016/j.bbapap.2005.03.014
dc.identifier.issn1570-9639
dc.identifier.urihttp://hdl.handle.net/11449/17561
dc.identifier.wosWOS:000229810800003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochimica et Biophysica Acta: Proteins and Proteomics
dc.relation.ispartofjcr2.609
dc.relation.ispartofsjr1,170
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcrystallizationpt
dc.subjectX-ray crystallographypt
dc.subjectimportin-alphapt
dc.subjectkaryopherin-alphapt
dc.subjectnuclear localization sequencept
dc.subjectNLS peptidomimetic ligandpt
dc.titleCrystallization and preliminary X-ray diffraction analysis of importin-alpha acomplexed with NLS peptidomimeticsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.orcid0000-0003-1753-1433[4]
unesp.author.orcid0000-0001-9413-9166[6]
unesp.author.orcid0000-0002-5684-1322[5]
unesp.author.orcid0000-0002-4634-6221[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFísica e Biofísica - IBBpt

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Botucatu - IBB - Instituto de Biociências