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Ceratoplastia lamelar em coelhos usando enxerto de omento al�geno livre e c�lulas mesenquimais omentais associadas com membrana amni�tica canina

dc.contributor.authorDe Barros, S�fora Vieira Da Silva Gouv�a [UNESP]
dc.contributor.authorAldrovani, Marcela [UNESP]
dc.contributor.authorDe Lacerda, Luciana Cen�o Correa [UNESP]
dc.contributor.authorHorr, M�nica [UNESP]
dc.contributor.authorMarinho, F�bio Andrade [UNESP]
dc.contributor.authorLima, Tiago Barbalho [UNESP]
dc.contributor.authorDa Silveira, Camila Pinho Balthazar [UNESP]
dc.contributor.authorBrito, F�bio Luiz Da Cunha [UNESP]
dc.contributor.authorBassaneze, Vin�cius
dc.contributor.authorFlecher, Mayra Cunha
dc.contributor.authorBeltrame, Renato Travassos
dc.contributor.authorNakamuta, Juliana Sanajotti
dc.contributor.authorKrieger, Jos� Eduardo
dc.contributor.authorLaus, Jos� Luiz [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:05:01Z
dc.date.available2018-12-11T17:05:01Z
dc.date.issued2016-10-01
dc.description.abstractThe objective of this research was to evaluate the clinical and microscopic effects in rabbits of lamellar keratoplasty using allogeneic omentum associated with canine amniotic membrane (AM). Rabbits were divided into two groups: one received the allogeneic free omental graft covered with the AM (OM-graft group), while the other received the AM graft containing omental mesenchymal cells (OM-cell group). Clinical signs were evaluated on different postoperative days. After the clinical assessments, the rabbits were euthanized and their corneas were obtained for histopathology and immunohistochemistry (Ki-67, marker for proliferation). Both groups showed chemosis, blepharospasm, eye discharge, hyperemia, and corneal opacity/ edema. Neovascularization was observed in the OM-cell group. Histopathological evaluation revealed epithelial islands within the stroma of OM-cell samples. Thirty days after surgery, complete corneal re-epithelialization had occurred in both groups. The OM cell group showed more Ki-67 positive cells. The free omentum and its cells, combined with the AM, contributed to corneal repair, a process that was completed 30 days after lamellar keratoplasty.en
dc.description.affiliationDepartamento de Cl�nica e Cirurgia Faculdade de Ci�ncias Agr�rias e Veterin�rias (FCAV) Universidade Estadual Paulista (UNESP), Campus de Jaboticabal
dc.description.affiliationInstituto do Cora��o (InCor) Escola de Medicina Universidade de S�o Paulo (USP)
dc.description.affiliationUnespDepartamento de Cl�nica e Cirurgia Faculdade de Ci�ncias Agr�rias e Veterin�rias (FCAV) Universidade Estadual Paulista (UNESP), Campus de Jaboticabal
dc.format.extent1838-1845
dc.identifierhttp://dx.doi.org/10.1590/0103-8478cr20151348
dc.identifier.citationCiencia Rural, v. 46, n. 10, p. 1838-1845, 2016.
dc.identifier.doi10.1590/0103-8478cr20151348
dc.identifier.fileS0103-84782016001001838.pdf
dc.identifier.issn1678-4596
dc.identifier.issn0103-8478
dc.identifier.scieloS0103-84782016001001838
dc.identifier.scopus2-s2.0-84983504237
dc.identifier.urihttp://hdl.handle.net/11449/173400
dc.language.isoeng
dc.relation.ispartofCiencia Rural
dc.relation.ispartofsjr0,337
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAmniotic membrane
dc.subjectCornea
dc.subjectOmentum
dc.subjectProgenitor cells
dc.subjectWound healing
dc.titleCeratoplastia lamelar em coelhos usando enxerto de omento al�geno livre e c�lulas mesenquimais omentais associadas com membrana amni�tica caninapt
dc.title.alternativeLamellar keratoplasty in rabbits using an allogeneic free omental graft and omentum-derived mesenchymal cells associated with the canine amniotic membraneen
dc.typeArtigo
dspace.entity.typePublication
unesp.departmentClínica e Cirurgia Veterinária - FCAVpt

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