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The Effect of Supra- and Subphysiologic Testosterone Levels on Ligature-Induced Bone Loss in Rats - A Radiographic and Histologic Pilot Study

dc.contributor.authorSteffens, Joao P. [UNESP]
dc.contributor.authorCoimbra, Leila S. [UNESP]
dc.contributor.authorRamalho-Lucas, Pablo D. [UNESP]
dc.contributor.authorRossa, Carlos [UNESP]
dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:46:01Z
dc.date.available2014-05-20T13:46:01Z
dc.date.issued2012-11-01
dc.description.abstractBackground: Testosterone is the primary male sexual hormone, and varying concentrations of the hormone mediated by physiologic, pathologic, or pharmacologic mechanisms may induce large variations in the body. Data regarding the general role of testosterone in mediating inflammation are still inconclusive. Therefore, the purpose of this study is to assess the consequences of supra- and subphysiologic levels of testosterone on ligature-induced bone loss in rats.Methods: Three male adult Holtzman rats were used to observe the course of serum testosterone concentration following orchiectomy (Ocx) and testosterone injections. Another 60 rats were randomly assigned to the following groups: 1) sham-operation controls (n = 10); 2) sham-operation and ligature-induced bone loss (n = 10); 3) orchiectomy without ligature (Ocx; n = 10); 4) Ocx and ligature (n = 10); 5) Ocx plus 250 mg/kg body weight intramuscular testosterone esters injection without ligature (Ocx+T; n = 10); and 6) Ocx, T, and ligature (n = 10). The ligatures were placed 30 days post-orchiectomy (or sham-operation) and maintained for 15 days. Thereafter, the rats were sacrificed, and their hemimandibles were used for radiographic evaluation of bone loss along with histologic and histometric analyses of gingival tissue.Results: The results indicated a significant increase in bone loss in the Ocx and Ocx+T groups in the presence and absence of inflammation, respectively. In addition, the Ocx and Ocx+T groups presented increased gingival area accompanying ligature-induced bone loss.Conclusions: Both sub- and supraphysiologic testosterone levels may influence bone metabolism, but only subphysiologic levels significantly increase ligature-induced bone loss. Moreover, testosterone has a regulatory effect on the gingival area. J Periodontol 2012;83:1432-1439.en
dc.description.affiliationSão Paulo State Univ, Sch Dent Araraquara, Dept Physiol & Pathol, São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Diag & Surg, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent Araraquara, Dept Physiol & Pathol, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Diag & Surg, São Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 10/09658-0
dc.description.sponsorshipIdFAPESP: 10/12021-4
dc.format.extent1432-1439
dc.identifierhttp://dx.doi.org/10.1902/jop.2012.110658
dc.identifier.citationJournal of Periodontology. Chicago: Amer Acad Periodontology, v. 83, n. 11, p. 1432-1439, 2012.
dc.identifier.doi10.1902/jop.2012.110658
dc.identifier.issn0022-3492
dc.identifier.lattes2640929291808415
dc.identifier.urihttp://hdl.handle.net/11449/16243
dc.identifier.wosWOS:000311266400013
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectBone remodelingen
dc.subjectgingival overgrowthen
dc.subjectinflammationen
dc.subjecttestosteroneen
dc.titleThe Effect of Supra- and Subphysiologic Testosterone Levels on Ligature-Induced Bone Loss in Rats - A Radiographic and Histologic Pilot Studyen
dc.typeArtigo
dcterms.licensehttp://www.joponline.org/page/permissionRequests.jsp
dcterms.rightsHolderAmer Acad Periodontology
dspace.entity.typePublication
unesp.author.lattes2640929291808415
unesp.author.lattes7634063102292261[4]
unesp.author.orcid0000-0003-1705-5481[4]
unesp.author.orcid0000-0002-6071-553X[1]
unesp.author.orcid0000-0002-0592-542X[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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