Publicação: Challenge with fumonisins B-1 and B-2 changes IGF-1 and GHR mRNA expression in liver of Nile tilapia fingerlings
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Wageningen Academic Publishers
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Although fumonisins are identified as responsible for alterations in weight gain, little information is available on their effects on expression of growth-related genes, especially for Nile tilapia (Oreochromis niloticus) fingerlings. In this study, Nile tilapia fingerlings were treated with increasing levels of fumonisin B-1 (FB1) and fumonisin B-2 (FB2) (diets of 0, 20, 40, and 60 mg/kg) to evaluate their effects on weight gain (WG), feed intake (FI), feed efficiency (FE), growth hormone receptor (GHR) and insulin growth factor 1 (IGF-1) mRNA expression in liver of this fish. All variables were evaluated at 15 and 30 days of treatment. Diet containing 0 mg fumonisin/kg was used as control treatment. Treatment with 20, 40, and 60 mg fumonisin/kg of diet significantly reduced WG (P<0.0001) and FE (P<0.0001), while GHR and IGF-1 mRNA expression was reduced both at 15 and 30 days of treatment. Feed intake was not affected by diets in any of the evaluated periods. These results indicate that fumonisins (FB1 + FB2) affect the growth of Nile tilapia fingerlings through mechanisms that involve reduction of GHR and IGF-1 expression.
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Fusarium proliferatum, gene expression, growth hormone receptor, insulin growth factor 1, Oreochromis niloticus
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Inglês
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World Mycotoxin Journal. Wageningen: Wageningen Academic Publishers, v. 11, n. 2, p. 237-245, 2018.
