Development of an oral mucosa equivalent using a porcine dermal matrix
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We evaluated the suitability of a porcine acellular dermal matrix for the development of a 3-dimensional oral mucosal equivalent using an ex vivo-produced oral mucosal equivalent (EVPOME). Oral keratinocytes were seeded in a submerged model, and then in an air-liquid interphase model, using Transwell® inserts. EVPOME showed good cell viability and increased glucose consumption over time. Histological evaluation showed that stratified differentiated epithelium had formed in all matrices.
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Oral keratinocytes, oral mucosa, organotypic cell culture
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British Journal of Oral and Maxillofacial Surgery, v. 55, n. 3, p. 308-311, 2017.
