Mandible metastasis as the first sign from primary adenocarcinoma of the lung
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Adenocarcinoma of the lung that metastasizes to the mandible is very uncommon; only a few cases have been described in the English-language literature. This article presents a metastasis from adenocarcinoma of the lung affecting the mandible of a 64-year-old woman, in which the first discovered metastatic lesion was detected before the primary tumor. The immunoreactivity for human thyroid transcription factor-1 (TTF-1) in the oral lesion was essential for determining the site and type of the primary tumor, as the patient showed no clinical or radiographic evidence of a tumor in the thyroid gland. After the primary tumor in the lung was diagnosed, radiotherapy and chemotherapy were initiated; unfortunately, the patient died two months after the start of treatment. This article emphasizes the importance of a well-conducted examination for diagnosing metastatic oral lesions.
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homeodomain protein , nuclear protein , thyroid nuclear factor 1 , transcription factor , unclassified drug , adenocarcinoma , case report , fatality , female , human , lung tumor , mandible tumor , metastasis , middle aged , pathology , skull tumor , Adenocarcinoma , Fatal Outcome , Female , Homeodomain Proteins , Humans , Lung Neoplasms , Mandibular Neoplasms , Middle Aged , Nuclear Proteins , Skull Neoplasms , Transcription Factors
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General Dentistry, v. 55, n. 3, p. 224-227, 2007.
