Logotipo do repositório
 

Publicação:
The in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiaca

Página do item simplificado
dc.contributor.authorMelo, Fernando L.
dc.contributor.authorBenati, Fabricio J.
dc.contributor.authorRoman, Walter Antonio [UNESP]
dc.contributor.authorPalazzo de Mello, Joao Carlos
dc.contributor.authorNozawa, Carlos
dc.contributor.authorCarvalho Linhares, Rosa Elisa
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.date.accessioned2014-05-20T15:34:30Z
dc.date.available2014-05-20T15:34:30Z
dc.date.issued2008-01-01
dc.description.abstractWe investigated the antiviral activity of an aliphatic nitro compound (NC) isolated from Heteropteris aphrodisiaca O. Mach. (Malpighiaceae), a Brazilian medicinal ptant. The NC was tested for its antiviral activity against poliovirus type 1 (PV-1) and bovine herpes virus type 1 (BHV-1) by plaque reduction assay in cell culture. The NC showed a moderate antiviral activity against PV-1 and BHV-1 in HEp-2 celts, and the 50% inhibitory concentration (IC50) were 22.01 mu g/ml (selectivity index (SI) = 2.83) and 21.10 mu g/mi (SI = 2.95), respectivety. At the highest concentration of the drug (40 mu g/ml) a reduction of approximately 80% in plaque assay was observed for both viruses. The treatment of cells or virus prior to infection did not inhibit the replication of virus strains. (C) 2006 Elsevier GmbH. All rights reserved.en
dc.description.affiliationUniversidade Estadual de Londrina (UEL), Dept Microbiol CCB, BR-86051990 Londrina, Parana, Brazil
dc.description.affiliationUniv Estadual Paulista, PPG Ciencias Farmaceut, Araraquara, SP, Brazil
dc.description.affiliationUniversidade Estadual de Maringá (UEM), Dept Farm & Farmacol, Maringa, Parana, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, PPG Ciencias Farmaceut, Araraquara, SP, Brazil
dc.format.extent136-139
dc.identifierhttp://dx.doi.org/10.1016/j.micres.2006.03.011
dc.identifier.citationMicrobiological Research. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 163, n. 2, p. 136-139, 2008.
dc.identifier.doi10.1016/j.micres.2006.03.011
dc.identifier.fileWOS000254531400003.pdf
dc.identifier.issn0944-5013
dc.identifier.urihttp://hdl.handle.net/11449/42556
dc.identifier.wosWOS:000254531400003
dc.language.isoeng
dc.publisherElsevier Gmbh, Urban & Fischer Verlag
dc.relation.ispartofMicrobiological Research
dc.relation.ispartofjcr2.777
dc.relation.ispartofsjr1,030
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectHeteropteris ophrodisiacaen
dc.subjectaliphatic nitro compounden
dc.subjectpoliovirusen
dc.subjectantiviral activityen
dc.subjectbovine herpesvirusen
dc.titleThe in vitro antiviral activity of an aliphatic nitro compound from Heteropteris aphrodisiacaen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier Gmbh, Urban & Fischer Verlag
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
WOS000254531400003.pdf
Tamanho:
127.44 KB
Formato:
Adobe Portable Document Format
Baixar

Licença do Pacote

Agora exibindo 1 - 2 de 2
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Imagem de Miniatura
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Descrição:

Coleções

Araraquara - FCF - Faculdade de Ciências Farmacêuticas