Prospective study for the development of emulsion systems containing natural oil products
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Abstract
Copaiba oil, when used as anti-inflammatory and anti-infective agent, presents two major problems: i) low absorption and bioavailability and ii) an unpleasant taste. Once an appropriate emulsion was achieved, the samples were prepared using different surfactant binary mixtures to obtain a range of HLB values between 45 and 16.5. The HLB value of copaiba oil was 14.8; this system has been stable for more than one year, and the pseudo-ternary diagrams were useful to describe the component proportions. These results indicated that the copaiba oil emulsion might be a promising vehicle for topical delivery of drugs and active cosmetic ingredients.
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Keywords
Copaiba oil, Emulsion, Hydrophilic-lipophilic balance, Pseudo-ternary phase diagram, Stability analysis
Language
English
Citation
Journal of Drug Delivery Science and Technology, v. 22, n. 4, p. 367-372, 2012.
