Bone healing in critical-size defects treated with bioactive glass/calcium sulfate: A histologic and histometric study in rat calvaria
dc.contributor.author | Furlaneto, Flávia A. C. [UNESP] | |
dc.contributor.author | Nagata, Maria José Hitomi [UNESP] | |
dc.contributor.author | Fucini, Stephen E. | |
dc.contributor.author | Deliberador, Tatiana M. [UNESP] | |
dc.contributor.author | Okamoto, Tetuo [UNESP] | |
dc.contributor.author | Messora, Michel R. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Private Practice | |
dc.date.accessioned | 2014-05-27T11:22:29Z | |
dc.date.available | 2014-05-27T11:22:29Z | |
dc.date.issued | 2007-06-01 | |
dc.description.abstract | Objective: The purpose of this study was to analyze histologically the influence of bioactive glass (BG) with or without a calcium sulfate (CS) barrier on bone healing in surgically created critical-size defects (CSD) in rat calvaria. Material and methods: A CSD was made in each calvarium of 48 rats. They were divided into three groups: C (control): blood clot only; BG: defect filled with BG; and BG/CS: defect filled with BG covered by a CS barrier. Animals were euthanized at 4 or 12 weeks. Formation of new bone was evaluated histomorphometrically. Results: No defect completely regenerated with bone. BG particles were observed in Groups BG and BG/CS at both periods of analysis. The thickness throughout the healing area in Groups BG and BG/CS was similar to the original calvarium, while Group C presented a thin connective tissue in the center of the defect in both periods of analysis. At 4 weeks, Groups C and BG/CS presented significantly more bone formation than Group BG. No significant differences were found between Groups C and BG/CS. At 12 weeks, no significant differences in the amount of bone formation were observed among the three groups. When comparing 4 and 12 weeks, there was a significant increase in new bone formation within groups BG and BG/CS, but not C. Conclusion: BG particles, used with or without a CS barrier, maintained the volume and contour of the area grafted in CSD. However, they did not lead to a significant difference in bone formation when compared with control at 12 weeks post-operative. © 2007 Blackwell Munksgaard. | en |
dc.description.affiliation | Department of Surgery and Integrated Clinic Dental School of Araçatuba University of the State of São Paulo Júlio de Mesquita Filho - UNESP | |
dc.description.affiliation | Private Practice, Hanover, NH | |
dc.description.affiliation | , Rua Afonso Pena, 325 - Apt. 51, CEP: 16010-370 Aracatuba, SP | |
dc.description.affiliationUnesp | Department of Surgery and Integrated Clinic Dental School of Araçatuba University of the State of São Paulo Júlio de Mesquita Filho - UNESP | |
dc.format.extent | 311-318 | |
dc.identifier | http://dx.doi.org/10.1111/j.1600-0501.2006.01331.x | |
dc.identifier.citation | Clinical Oral Implants Research, v. 18, n. 3, p. 311-318, 2007. | |
dc.identifier.doi | 10.1111/j.1600-0501.2006.01331.x | |
dc.identifier.issn | 0905-7161 | |
dc.identifier.issn | 1600-0501 | |
dc.identifier.lattes | 8399870097572073 | |
dc.identifier.lattes | 0169955363968097 | |
dc.identifier.scopus | 2-s2.0-34547190602 | |
dc.identifier.uri | http://hdl.handle.net/11449/69680 | |
dc.language.iso | eng | |
dc.relation.ispartof | Clinical Oral Implants Research | |
dc.relation.ispartofjcr | 4.305 | |
dc.relation.ispartofsjr | 2,462 | |
dc.relation.ispartofsjr | 2,462 | |
dc.rights.accessRights | Acesso restrito | pt |
dc.source | Scopus | |
dc.subject | Bioactive | |
dc.subject | Bone regeneration | |
dc.subject | Bone substitutes | |
dc.subject | Calcium sulfate | |
dc.subject | Glass | |
dc.subject | Biogran | |
dc.subject | biomaterial | |
dc.subject | calcium sulfate | |
dc.subject | glass | |
dc.subject | unclassified drug | |
dc.subject | animal | |
dc.subject | bone regeneration | |
dc.subject | cytology | |
dc.subject | drug effect | |
dc.subject | male | |
dc.subject | randomization | |
dc.subject | rat | |
dc.subject | skull | |
dc.subject | Wistar rat | |
dc.subject | Animals | |
dc.subject | Biocompatible Materials | |
dc.subject | Bone Regeneration | |
dc.subject | Calcium Sulfate | |
dc.subject | Male | |
dc.subject | Random Allocation | |
dc.subject | Rats | |
dc.subject | Rats, Wistar | |
dc.subject | Skull | |
dc.title | Bone healing in critical-size defects treated with bioactive glass/calcium sulfate: A histologic and histometric study in rat calvaria | en |
dc.type | Artigo | pt |
dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dspace.entity.type | Publication | |
relation.isOrgUnitOfPublication | 8b3335a4-1163-438a-a0e2-921a46e0380d | |
relation.isOrgUnitOfPublication.latestForDiscovery | 8b3335a4-1163-438a-a0e2-921a46e0380d | |
unesp.author.lattes | 8399870097572073 | |
unesp.author.lattes | 0169955363968097 | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatuba | pt |
unesp.department | Cirurgia e Clínica Integrada - FOA | pt |