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Probiotic Therapy Reduces Periodontal Tissue Destruction and Improves the Intestinal Morphology in Rats With Ligature-Induced Periodontitis

dc.contributor.authorMessora, Michel R.
dc.contributor.authorOliveira, Luiz F. F.
dc.contributor.authorFoureaux, Renata C.
dc.contributor.authorTaba, Mario
dc.contributor.authorZangeronimo, Marcio G.
dc.contributor.authorFurlaneto, Flavia A. C. [UNESP]
dc.contributor.authorPereira, Luciano J.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionLavras Univ Ctr
dc.contributor.institutionUniversidade Federal de Lavras (UFLA)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:42Z
dc.date.available2014-12-03T13:10:42Z
dc.date.issued2013-12-01
dc.description.abstractBackground: With increase in the incidence of resistance to antibiotics, probiotics are emerging as a promising adjunctive periodontal therapy. The authors of this study evaluate the influence of probiotic (PROB) supplementation on ligature-induced periodontitis (LIP) and intestinal morphology in rats.Methods: Thirty-two rats were randomly divided into four groups: control (C), LIP, PROB, and LIP/PROB. In groups PROB and LIP/PROB, the PROB was administered orally by addition to the drinking water of the animals for 44 days. In groups LIP and LIP/PROB, the mandibular right first molar of the animals received a cotton ligature that was left in the same position for 14 days. All animals were euthanized 44 days after the start of the PROB supplementation. The jaws were resected and histomorphometric analyses were performed. The measurements included evaluation of attachment loss (AL) and alveolar bone level (ABL) on the distal root of the mandibular first molar. Samples of the duodenum, jejunum, and ileum were also dissected from each animal to evaluate the villous height (VH) and crypt depth (CD). The data obtained were subjected to statistical analyses (analysis of variance, Tukey; P <0.05).Results: Mean values of AL and ABL were significantly higher in group LIP compared with group LIP/PROB (AL: 3.05 +/- 0.57 mm and 1.78 +/- 0.63 mm, respectively; ABL: 4.21 +/- 0.42 mm and 3.38 +/- 0.17 mm, respectively). In group LIP/PROB, the mean values of VH and CD of the jejunum were significantly higher than the ones from group LIP (VH: 672.1 +/- 83.3 mu m and 528.0 +/- 51.7 mu m, respectively; CD: 463.8 +/- 100.9 mu m and 269.0 +/- 48.4 mu m, respectively).Conclusions: It can be concluded that PROB supplementation 1) reduces AL and alveolar bone loss in rats with LIP and 2) can protect the small intestine from reactive changes induced by LIP.en
dc.description.affiliationUniv Sao Paulo, Sch Dent Ribeirao Preto, Dept Oral & Maxillofacial Surg & Periodontol, BR-14040904 Sao Paulo, Brazil
dc.description.affiliationLavras Univ Ctr, Sch Dent, Lavras, MG, Brazil
dc.description.affiliationUniv Fed Lavras, Dept Physiol & Pharmacol, Lavras, MG, Brazil
dc.description.affiliationSao Paulo State Univ, Dent Sch Aracatuba, Dept Surg & Integrated Clin, Div Periodont, Sao Paulo, Brazil
dc.description.affiliationUnespSao Paulo State Univ, Dent Sch Aracatuba, Dept Surg & Integrated Clin, Div Periodont, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdCNPq: 475468/2010-4
dc.format.extent1818-1826
dc.identifierhttp://dx.doi.org/10.1902/jop.2013.120644
dc.identifier.citationJournal Of Periodontology. Chicago: Amer Acad Periodontology, v. 84, n. 12, p. 1818-1826, 2013.
dc.identifier.doi10.1902/jop.2013.120644
dc.identifier.issn0022-3492
dc.identifier.urihttp://hdl.handle.net/11449/112423
dc.identifier.wosWOS:000328686300016
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectAlveolar bone lossen
dc.subjectBacillus subtilisen
dc.subjectintestinal mucosaen
dc.subjectperiodontitisen
dc.subjectprobioticsen
dc.subjectratsen
dc.titleProbiotic Therapy Reduces Periodontal Tissue Destruction and Improves the Intestinal Morphology in Rats With Ligature-Induced Periodontitisen
dc.typeArtigopt
dcterms.rightsHolderAmer Acad Periodontology
dspace.entity.typePublication
relation.isOrgUnitOfPublication8b3335a4-1163-438a-a0e2-921a46e0380d
relation.isOrgUnitOfPublication.latestForDiscovery8b3335a4-1163-438a-a0e2-921a46e0380d
unesp.author.orcid0000-0001-8485-9645[1]
unesp.author.orcid0000-0002-7098-5090[4]
unesp.author.orcid0000-0002-8072-3983[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentCirurgia e Clínica Integrada - FOApt

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