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NLRP1 L155H polymorphism is a risk factor for preeclampsia development

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dc.contributor.authorPontillo, Alessandra
dc.contributor.authorReis, Edione C.
dc.contributor.authorBricher, Pamela N.
dc.contributor.authorVianna, Priscila
dc.contributor.authorDiniz, Solange
dc.contributor.authorFernandes, Karla S.
dc.contributor.authorChies, José A.
dc.contributor.authorSandrim, Valeria [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRS)
dc.contributor.institutionSanta Casa de Belo Horizonte
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-21T13:11:06Z
dc.date.available2015-10-21T13:11:06Z
dc.date.issued2015-06-01
dc.description.abstractProblem: Augmented levels of IL-1 ss have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1 ss cleavage and IL-1 ss secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome'genes and preeclampsia. Method of study: Selected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia. Results and Conlclusions: The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR=1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.en
dc.description.affiliationUniversidade de São Paulo, Departamento de Imunologia, Instituto de Ciências Biomédicas
dc.description.affiliationUniversidade Federal do Rio Grande do Sul, Departamento de Genética
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Farmacologia, Instituto de Biociências de Botucatu
dc.format.extent577-581
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/aji.12353/abstract
dc.identifier.citationAmerican Journal Of Reproductive Immunology. Hoboken: Wiley-blackwell, v. 73, n. 6, p. 577-581, 2015.
dc.identifier.doi10.1111/aji.12353
dc.identifier.issn1046-7408
dc.identifier.urihttp://hdl.handle.net/11449/128571
dc.identifier.wosWOS:000354390000010
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAmerican Journal Of Reproductive Immunology
dc.relation.ispartofjcr2.745
dc.relation.ispartofsjr1,210
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectIL-1 ssen
dc.subjectInflammasomeen
dc.subjectNLRP1en
dc.subjectPreeclampsiaen
dc.titleNLRP1 L155H polymorphism is a risk factor for preeclampsia developmenten
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-Blackwell
dspace.entity.typePublication
unesp.author.orcid0000-0002-6168-7470[8]
unesp.author.orcid0000-0001-7025-0660[7]
unesp.author.orcid0000-0002-7883-0640[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentFarmacologia - IBBpt

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Botucatu - IBB - Instituto de Biociências