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Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants

dc.contributor.authorConte Neto, Nicolau
dc.contributor.authorde Andrade, Cleverton Roberto
dc.contributor.authorSpolidorio, Luis Carlos
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorCruz, Fábio Cardoso
dc.contributor.authorde Souza Bastos, Alliny
dc.contributor.authorMarcantonio, Elcio
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:38Z
dc.date.available2014-05-27T11:28:38Z
dc.date.issued2013-03-04
dc.description.abstractPurposes: The purposes of this study were to evaluate the influence of chronic stress (CS) on implant osseointegration and also to analyze whether alendronate (ALN) therapy could prevent these eventual stress-negative effects. Materials and Methods: Adult male Holtzmann rats were assigned to one of the four experimental groups: AL (ALN; 1mg/kg/week; n=12), ALS (ALN+CS; 1mg/kg/week; n=12), CTL (sterile physiological saline; n=12), or CTLS (sterile physiological saline+CS; n=12). After 58 days of drug therapy, the ALS and CTLS groups were exposed to CS, and 2 days later all animals underwent tibial implant installation. The animals were euthanized 28 days following the operative surgical procedure. Results: It was observed that the CTLS group presented an impairment of bone metabolism represented by lowest levels of bone-specific alkaline phosphatase and bone area fraction occupancy values. Furthermore, these animals presented a higher proportion of empty osteocytic lacunae. In contrast, the ALN therapy showed increased osseointegration and torque value parameters, regardless of stress exposition. Conclusions: Analysis of the data presented suggests that CS partially impairs the osseointegration of tibial implants and that ALN therapy is able to prevent these negative effects. © 2013 Wiley Periodicals, Inc.en
dc.identifierhttp://dx.doi.org/10.1111/cid.12046
dc.identifier.citationClinical Implant Dentistry and Related Research.
dc.identifier.doi10.1111/cid.12046
dc.identifier.issn1523-0899
dc.identifier.issn1708-8208
dc.identifier.lattes2514762545280942
dc.identifier.lattes2640929291808415
dc.identifier.lattes2402682969776875
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.orcid0000-0001-7015-7175
dc.identifier.scopus2-s2.0-84874356193
dc.identifier.urihttp://hdl.handle.net/11449/74796
dc.language.isoeng
dc.relation.ispartofClinical Implant Dentistry and Related Research
dc.relation.ispartofjcr3.097
dc.relation.ispartofsjr1,827
dc.rights.accessRightsAcesso restritopt
dc.sourceScopus
dc.subjectAlendronate
dc.subjectBone
dc.subjectOperative surgical procedure
dc.subjectOsseointegration
dc.titleEffects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implantsen
dc.typeArtigopt
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes2640929291808415
unesp.author.lattes2514762545280942[4]
unesp.author.lattes2402682969776875[2]
unesp.author.orcid0000-0002-9660-4524[7]
unesp.author.orcid0000-0002-1378-6327[4]
unesp.author.orcid0000-0001-7015-7175[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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