Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants
dc.contributor.author | Conte Neto, Nicolau | |
dc.contributor.author | de Andrade, Cleverton Roberto | |
dc.contributor.author | Spolidorio, Luis Carlos | |
dc.contributor.author | Planeta, Cleopatra da Silva [UNESP] | |
dc.contributor.author | Cruz, Fábio Cardoso | |
dc.contributor.author | de Souza Bastos, Alliny | |
dc.contributor.author | Marcantonio, Elcio | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-27T11:28:38Z | |
dc.date.available | 2014-05-27T11:28:38Z | |
dc.date.issued | 2013-03-04 | |
dc.description.abstract | Purposes: The purposes of this study were to evaluate the influence of chronic stress (CS) on implant osseointegration and also to analyze whether alendronate (ALN) therapy could prevent these eventual stress-negative effects. Materials and Methods: Adult male Holtzmann rats were assigned to one of the four experimental groups: AL (ALN; 1mg/kg/week; n=12), ALS (ALN+CS; 1mg/kg/week; n=12), CTL (sterile physiological saline; n=12), or CTLS (sterile physiological saline+CS; n=12). After 58 days of drug therapy, the ALS and CTLS groups were exposed to CS, and 2 days later all animals underwent tibial implant installation. The animals were euthanized 28 days following the operative surgical procedure. Results: It was observed that the CTLS group presented an impairment of bone metabolism represented by lowest levels of bone-specific alkaline phosphatase and bone area fraction occupancy values. Furthermore, these animals presented a higher proportion of empty osteocytic lacunae. In contrast, the ALN therapy showed increased osseointegration and torque value parameters, regardless of stress exposition. Conclusions: Analysis of the data presented suggests that CS partially impairs the osseointegration of tibial implants and that ALN therapy is able to prevent these negative effects. © 2013 Wiley Periodicals, Inc. | en |
dc.identifier | http://dx.doi.org/10.1111/cid.12046 | |
dc.identifier.citation | Clinical Implant Dentistry and Related Research. | |
dc.identifier.doi | 10.1111/cid.12046 | |
dc.identifier.issn | 1523-0899 | |
dc.identifier.issn | 1708-8208 | |
dc.identifier.lattes | 2514762545280942 | |
dc.identifier.lattes | 2640929291808415 | |
dc.identifier.lattes | 2402682969776875 | |
dc.identifier.orcid | 0000-0002-1378-6327 | |
dc.identifier.orcid | 0000-0001-7015-7175 | |
dc.identifier.scopus | 2-s2.0-84874356193 | |
dc.identifier.uri | http://hdl.handle.net/11449/74796 | |
dc.language.iso | eng | |
dc.relation.ispartof | Clinical Implant Dentistry and Related Research | |
dc.relation.ispartofjcr | 3.097 | |
dc.relation.ispartofsjr | 1,827 | |
dc.rights.accessRights | Acesso restrito | pt |
dc.source | Scopus | |
dc.subject | Alendronate | |
dc.subject | Bone | |
dc.subject | Operative surgical procedure | |
dc.subject | Osseointegration | |
dc.title | Effects of Chronic Stress and Alendronate Therapy on the Osseointegration of Titanium Implants | en |
dc.type | Artigo | pt |
dcterms.license | http://olabout.wiley.com/WileyCDA/Section/id-406071.html | |
dspace.entity.type | Publication | |
relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
unesp.author.lattes | 2640929291808415 | |
unesp.author.lattes | 2514762545280942[4] | |
unesp.author.lattes | 2402682969776875[2] | |
unesp.author.orcid | 0000-0002-9660-4524[7] | |
unesp.author.orcid | 0000-0002-1378-6327[4] | |
unesp.author.orcid | 0000-0001-7015-7175[2] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Princípios Ativos Naturais e Toxicologia - FCF | pt |