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Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives

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dc.contributor.authorSantos, Jean L. [UNESP]
dc.contributor.authorYamasaki, Paulo R. [UNESP]
dc.contributor.authorChin, Chung Man [UNESP]
dc.contributor.authorTakashi, Celio H. [UNESP]
dc.contributor.authorPavan, Fernando Rogério [UNESP]
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:14Z
dc.date.available2014-05-20T13:24:14Z
dc.date.issued2009-06-01
dc.description.abstractNew phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70-90%). All compounds (3a-l) were evaluated against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 mu/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Lapdesf Lab Pesquisa & Desenvolvimento Farmacos, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Ciencias Biol, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 07/54983-4
dc.description.sponsorshipIdFAPESP: 07/561150
dc.description.sponsorshipIdFAPESP: 08/10390-2
dc.format.extent3795-3799
dc.identifierhttp://dx.doi.org/10.1016/j.bmc.2009.04.042
dc.identifier.citationBioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 17, n. 11, p. 3795-3799, 2009.
dc.identifier.doi10.1016/j.bmc.2009.04.042
dc.identifier.issn0968-0896
dc.identifier.lattes9734333607975413
dc.identifier.lattes2114570774349859
dc.identifier.orcid0000-0003-4141-0455
dc.identifier.urihttp://hdl.handle.net/11449/7458
dc.identifier.wosWOS:000266117400007
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofBioorganic & Medicinal Chemistry
dc.relation.ispartofjcr2.881
dc.relation.ispartofsjr0,871
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectPhthalimide derivativesen
dc.subjectAntimycobacterialen
dc.subjectAntitubercular activityen
dc.subjectCytotoxicityen
dc.titleSynthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivativesen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dspace.entity.typePublication
relation.isDepartmentOfPublication5004bcab-94af-4939-b980-091ae9d0a19e
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscovery5004bcab-94af-4939-b980-091ae9d0a19e
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes2114570774349859
unesp.author.lattes9734333607975413[3]
unesp.author.orcid0000-0003-4141-0455[3]
unesp.author.orcid0000-0002-2460-2829[1]
unesp.author.orcid0000-0002-6969-3963[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas