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Synthesis, cytotoxic activity and DNA interaction of Pd(II) complexes bearing N′-methyl-3,5-dimethyl-1-thiocarbamoylpyrazole

dc.contributor.authorBarra, Carolina V. [UNESP]
dc.contributor.authorRocha, Fillipe V. [UNESP]
dc.contributor.authorGautier, Arnaud
dc.contributor.authorMorel, Laurent
dc.contributor.authorQuilles, Marcela B. [UNESP]
dc.contributor.authorCarlos, Iracilda Z. [UNESP]
dc.contributor.authorTreu-Filho, Oswaldo [UNESP]
dc.contributor.authorFrem, Regina C.G. [UNESP]
dc.contributor.authorMauro, Antonio Eduardo [UNESP]
dc.contributor.authorNetto, Adelino V.G. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversité Blaise Pascal
dc.contributor.institutionGreD UMR 6247 CNRS
dc.date.accessioned2014-05-27T11:30:41Z
dc.date.available2014-05-27T11:30:41Z
dc.date.issued2013-09-13
dc.description.abstractA new series of complexes of general formulae [PdX2(tmdmPz)] {X = Cl (1), Br (2), I (3), SCN (4); tmdmPz = N′-methyl-3,5-dimethyl-1- thiocarbamoylpyrazole} have been synthesized and characterized by elemental analysis, molar conductivities, IR, 1H and 13C{ 1H} NMR spectroscopy. In these complexes, the tmdmPz coordinates to Pd(II) center as a neutral N,S-chelating ligand. The geometries of the complexes have been optimized with the DFT method. Cytotoxicity evaluation against LM3 (mammary adenocarcinoma) and LP07 (lung adenocarcinoma) cell lines indicated that complexes 1-4 were more active than cisplatin. The binding of the complexes with a purine base (guanosine) was investigated by 1H NMR and mass spectrometry, showing that the coordination of guanosine occurs through N7. Electrophoretic DNA migration studies showed that all of them modify the DNA tertiary structure. © 2013 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Instituto de Química de Araraquara Departamento de Química Geral e Inorgânica, P.O. Box 355, Araraquara, São Paulo 14801-970
dc.description.affiliationClermont-Université ICCF Université Blaise Pascal, F-63177 Aubière Cedex
dc.description.affiliationClermont-Université Université Blaise Pascal GreD UMR 6247 CNRS, 24 Avenue des Landais, 63177 Aubière Cedex
dc.description.affiliationUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises Clínicas, P.O. Box 502, Araraquara, São Paulo 14801-902
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Instituto de Química de Araraquara Departamento de Química Geral e Inorgânica, P.O. Box 355, Araraquara, São Paulo 14801-970
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises Clínicas, P.O. Box 502, Araraquara, São Paulo 14801-902
dc.format.extent214-220
dc.identifierhttp://dx.doi.org/10.1016/j.poly.2013.08.040
dc.identifier.citationPolyhedron, v. 65, p. 214-220.
dc.identifier.doi10.1016/j.poly.2013.08.040
dc.identifier.issn0277-5387
dc.identifier.lattes3300223970814448
dc.identifier.lattes7927677053650819
dc.identifier.orcid0000-0002-0057-7964
dc.identifier.scopus2-s2.0-84883640761
dc.identifier.urihttp://hdl.handle.net/11449/76555
dc.identifier.wosWOS:000326999200028
dc.language.isoeng
dc.relation.ispartofPolyhedron
dc.relation.ispartofjcr2.067
dc.relation.ispartofsjr0,472
dc.rights.accessRightsAcesso restritopt
dc.sourceScopus
dc.subjectCytotoxicity
dc.subjectDNA binding
dc.subjectN′-methyl-3,5-dimethyl-1-thiocarbamoylpyrazole
dc.subjectPalladium(II)
dc.subjectSpectroscopy
dc.titleSynthesis, cytotoxic activity and DNA interaction of Pd(II) complexes bearing N′-methyl-3,5-dimethyl-1-thiocarbamoylpyrazoleen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes3300223970814448[9]
unesp.author.lattes7927677053650819[10]
unesp.author.orcid0000-0002-0057-7964[10]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentQuímica Inorgânica - IQARpt

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