Publicação: Synthesis, cytotoxic activity and DNA interaction of Pd(II) complexes bearing N′-methyl-3,5-dimethyl-1-thiocarbamoylpyrazole
dc.contributor.author | Barra, Carolina V. [UNESP] | |
dc.contributor.author | Rocha, Fillipe V. [UNESP] | |
dc.contributor.author | Gautier, Arnaud | |
dc.contributor.author | Morel, Laurent | |
dc.contributor.author | Quilles, Marcela B. [UNESP] | |
dc.contributor.author | Carlos, Iracilda Z. [UNESP] | |
dc.contributor.author | Treu-Filho, Oswaldo [UNESP] | |
dc.contributor.author | Frem, Regina C.G. [UNESP] | |
dc.contributor.author | Mauro, Antonio Eduardo [UNESP] | |
dc.contributor.author | Netto, Adelino V.G. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Université Blaise Pascal | |
dc.contributor.institution | GreD UMR 6247 CNRS | |
dc.date.accessioned | 2014-05-27T11:30:41Z | |
dc.date.available | 2014-05-27T11:30:41Z | |
dc.date.issued | 2013-09-13 | |
dc.description.abstract | A new series of complexes of general formulae [PdX2(tmdmPz)] {X = Cl (1), Br (2), I (3), SCN (4); tmdmPz = N′-methyl-3,5-dimethyl-1- thiocarbamoylpyrazole} have been synthesized and characterized by elemental analysis, molar conductivities, IR, 1H and 13C{ 1H} NMR spectroscopy. In these complexes, the tmdmPz coordinates to Pd(II) center as a neutral N,S-chelating ligand. The geometries of the complexes have been optimized with the DFT method. Cytotoxicity evaluation against LM3 (mammary adenocarcinoma) and LP07 (lung adenocarcinoma) cell lines indicated that complexes 1-4 were more active than cisplatin. The binding of the complexes with a purine base (guanosine) was investigated by 1H NMR and mass spectrometry, showing that the coordination of guanosine occurs through N7. Electrophoretic DNA migration studies showed that all of them modify the DNA tertiary structure. © 2013 Elsevier Ltd. All rights reserved. | en |
dc.description.affiliation | Universidade Estadual Paulista (UNESP) Instituto de Química de Araraquara Departamento de Química Geral e Inorgânica, P.O. Box 355, Araraquara, São Paulo 14801-970 | |
dc.description.affiliation | Clermont-Université ICCF Université Blaise Pascal, F-63177 Aubière Cedex | |
dc.description.affiliation | Clermont-Université Université Blaise Pascal GreD UMR 6247 CNRS, 24 Avenue des Landais, 63177 Aubière Cedex | |
dc.description.affiliation | Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises Clínicas, P.O. Box 502, Araraquara, São Paulo 14801-902 | |
dc.description.affiliationUnesp | Universidade Estadual Paulista (UNESP) Instituto de Química de Araraquara Departamento de Química Geral e Inorgânica, P.O. Box 355, Araraquara, São Paulo 14801-970 | |
dc.description.affiliationUnesp | Universidade Estadual Paulista (UNESP) Faculdade de Ciências Farmacêuticas de Araraquara Departamento de Análises Clínicas, P.O. Box 502, Araraquara, São Paulo 14801-902 | |
dc.format.extent | 214-220 | |
dc.identifier | http://dx.doi.org/10.1016/j.poly.2013.08.040 | |
dc.identifier.citation | Polyhedron, v. 65, p. 214-220. | |
dc.identifier.doi | 10.1016/j.poly.2013.08.040 | |
dc.identifier.issn | 0277-5387 | |
dc.identifier.lattes | 3300223970814448 | |
dc.identifier.lattes | 7927677053650819 | |
dc.identifier.orcid | 0000-0002-0057-7964 | |
dc.identifier.scopus | 2-s2.0-84883640761 | |
dc.identifier.uri | http://hdl.handle.net/11449/76555 | |
dc.identifier.wos | WOS:000326999200028 | |
dc.language.iso | eng | |
dc.relation.ispartof | Polyhedron | |
dc.relation.ispartofjcr | 2.067 | |
dc.relation.ispartofsjr | 0,472 | |
dc.rights.accessRights | Acesso restrito | pt |
dc.source | Scopus | |
dc.subject | Cytotoxicity | |
dc.subject | DNA binding | |
dc.subject | N′-methyl-3,5-dimethyl-1-thiocarbamoylpyrazole | |
dc.subject | Palladium(II) | |
dc.subject | Spectroscopy | |
dc.title | Synthesis, cytotoxic activity and DNA interaction of Pd(II) complexes bearing N′-methyl-3,5-dimethyl-1-thiocarbamoylpyrazole | en |
dc.type | Artigo | pt |
dcterms.license | http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy | |
dspace.entity.type | Publication | |
relation.isDepartmentOfPublication | a83d26d6-5383-42e4-bb3c-2678a6ddc144 | |
relation.isDepartmentOfPublication.latestForDiscovery | a83d26d6-5383-42e4-bb3c-2678a6ddc144 | |
relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
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relation.isOrgUnitOfPublication.latestForDiscovery | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
unesp.author.lattes | 3300223970814448[9] | |
unesp.author.lattes | 7927677053650819[10] | |
unesp.author.orcid | 0000-0002-0057-7964[10] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Química, Araraquara | pt |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Análises Clínicas - FCF | pt |
unesp.department | Química Inorgânica - IQAR | pt |