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Genome-wide association studies for growth traits in buffaloes using the single step genomic BLUP

dc.contributor.authorAraujo Neto, Francisco Ribeiro de
dc.contributor.authorAbreu Santos, Daniel Jordan de
dc.contributor.authorFernandes Junior, Gerardo Alves [UNESP]
dc.contributor.authorAspilcueta-Borquis, Rusbel Raul [UNESP]
dc.contributor.authorNascimento, Andre Vieira do [UNESP]
dc.contributor.authorSeno, Leonardo de Oliveira
dc.contributor.authorTonhati, Humberto [UNESP]
dc.contributor.authorOliveira, Henrique Nunes de [UNESP]
dc.contributor.institutionInst Fed Goiano
dc.contributor.institutionUniv Maryland
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFundacao Univ Fed Grande Dourados
dc.date.accessioned2020-12-11T01:40:46Z
dc.date.available2020-12-11T01:40:46Z
dc.date.issued2019-11-01
dc.description.abstractGrowth traits are important for the profitability of buffalo breeding systems, since in general, these animals are raised both for meat and milk. In this study, the single-step genomic BLUP method was employed to prospect the genomic regions' associated with weight at standard ages of 100, 210, 365, and 550 days in a buffalo population, aiming to identify genes with stronger expression for those characteristics. We found 6, 1, 2, and 5 SNPs significantly associated (p value < 10(-5)) with weight at 100, 210, 365, and 550 days of age, respectively, where those SNPs respectively explained 0.164, 0.040, 0.044, and 0.213% of the additive variance of each trait. SNP AX-85099682 (BBU24) was significant for weight at 100, 210, and 365 days, indicating the existence of a possible QTL affecting the initial growth rate of buffaloes. All told, eight genes (CBLB, TRNAG-UCC, GADD45B, LOC112583811, MGAT4C, KCNMA1, SLC5A2, and TGFB1I1) were identified as candidates for the growth traits of buffaloes. However, molecular and gene expression studies are necessary to validate these genes for subsequent use in programs for genetic improvement of the species.en
dc.description.affiliationInst Fed Goiano, Campus Rio Verde, Rio Verde, Brazil
dc.description.affiliationUniv Maryland, College Pk, MD 20742 USA
dc.description.affiliationUniv Estadual Paulista, Campus Jaboticabal, Jaboticabal, SP, Brazil
dc.description.affiliationFundacao Univ Fed Grande Dourados, Dourados, MS, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Campus Jaboticabal, Jaboticabal, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: 420202/2016-1
dc.description.sponsorshipIdFAPESP: 2016/21213-0
dc.format.extent113-115
dc.identifierhttp://dx.doi.org/10.1007/s13353-019-00528-5
dc.identifier.citationJournal Of Applied Genetics. Heidelberg: Springer Heidelberg, v. 61, n. 1, p. 113-115, 2020.
dc.identifier.doi10.1007/s13353-019-00528-5
dc.identifier.issn1234-1983
dc.identifier.urihttp://hdl.handle.net/11449/197529
dc.identifier.wosWOS:000493487500002
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal Of Applied Genetics
dc.sourceWeb of Science
dc.subjectAnimal breeding
dc.subjectBubalus bubalis
dc.subjectDevelopment
dc.subjectGWAS
dc.titleGenome-wide association studies for growth traits in buffaloes using the single step genomic BLUPen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.orcid0000-0003-1064-5614[1]
unesp.author.orcid0000-0003-3009-5621[5]
unesp.author.orcid0000-0003-4714-3167[7]
unesp.departmentZootecnia - FCAVpt

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