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Bioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilis

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dc.contributor.authorChapla, Vanessa Mara [UNESP]
dc.contributor.authorZeraik, Maria Luiza [UNESP]
dc.contributor.authorXimenes, Valdecir F. [UNESP]
dc.contributor.authorZanardi, Lisineia Maria [UNESP]
dc.contributor.authorLopes, Márcia Nasser [UNESP]
dc.contributor.authorCavalheiro, Alberto José [UNESP]
dc.contributor.authorSilva, Dulce Helena Siqueira [UNESP]
dc.contributor.authorYoung, Maria Claudia M.
dc.contributor.authorFonseca, Luiz Marcos da [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorAraújo, Angela Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNucleo Pesquisa Fisiol & Bioquim
dc.date.accessioned2014-12-03T13:11:29Z
dc.date.available2014-12-03T13:11:29Z
dc.date.issued2014-05-01
dc.description.abstractChemical investigation of an acetonitrile fraction from the endophytic fungus Phomopsis sp. led to the isolation of the new natural product 2-hydroxy-alternariol (7) together with the known compounds cytochalasins J (1) and H (2), 5'-epialtenuene (3) and the mycotoxins alternariol monomethyl ether (AME, 4), alternariol (AOH, 5) and cytosporone C (6). The structure of the new compound was elucidated by using 1-D and 2-D NMR (nuclear magnetic resonance) and high resolution mass spectrometry. The cytochalasins J (1) and H (2) and AOH (5) exhibited potent inhibition of the total ROS (reactive oxygen species) produced by stimulated human neutrophils and acted as potent potential anti-inflammatory agents. Moreover, cytochalasin H (2) demonstrated antifungal and acetylcholinesterase enzyme (AChE) inhibition in vitro.en
dc.description.affiliationUniv Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol, Inst Quim Organ,Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationNucleo Pesquisa Fisiol & Bioquim, Inst Bot, BR-04301902 Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Fac Ciencias Farmaceut Araraquara, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol, Inst Quim Organ,Inst Quim, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Quim, Fac Ciencias, BR-17033360 Bauru, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Fac Ciencias Farmaceut Araraquara, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 10/52327-5
dc.description.sponsorshipIdFAPESP: 13/07600-3
dc.format.extent6597-6608
dc.identifierhttp://dx.doi.org/10.3390/molecules19056597
dc.identifier.citationMolecules. Basel: Mdpi Ag, v. 19, n. 5, p. 6597-6608, 2014.
dc.identifier.doi10.3390/molecules19056597
dc.identifier.fileWOS000337113000070.pdf
dc.identifier.issn1420-3049
dc.identifier.lattes4702004904231248
dc.identifier.orcid0000-0001-7616-9652
dc.identifier.orcid0000-0002-1516-7765
dc.identifier.urihttp://hdl.handle.net/11449/113198
dc.identifier.wosWOS:000337113000070
dc.language.isoeng
dc.publisherMdpi Ag
dc.relation.ispartofMolecules
dc.relation.ispartofjcr3.098
dc.relation.ispartofsjr0,855
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectsecondary metabolitesen
dc.subjectbioactivitiesen
dc.subjectendophytic fungien
dc.subjectPhomopsis sp.en
dc.subjectSenna spectabilisen
dc.titleBioactive Secondary Metabolites from Phomopsis sp., an Endophytic Fungus from Senna spectabilisen
dc.typeArtigo
dcterms.rightsHolderMdpi Ag
dspace.entity.typePublication
unesp.author.lattes4702004904231248[7]
unesp.author.lattes2518006820764120[6]
unesp.author.lattes0037579054083160[11]
unesp.author.orcid0000-0002-1516-7765[7]
unesp.author.orcid0000-0001-8214-9957[6]
unesp.author.orcid0000-0001-7616-9652[11]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências, Baurupt
unesp.departmentQuímica - FCpt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentQuímica Orgânica - IQARpt

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Araraquara - IQAR - Instituto de Química
Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Bauru - FC - Faculdade de Ciências