Assessment of the endectocide efficacy of a pour-on topical solution containing fluazuron, fipronil and eprinomectin in cattle

The present study aimed to evaluate the effectiveness of a new formulation composed of the chemical active ingredients benzoylphenylurea, phenylpyrazole and macrocyclic lactone, which have different mechanisms of action on the most important parasites, such as R. microplus, H. irritans, D. hominis larvae, C. hominivorax larvae and nematodes. The six experiments were conducted in Formiga (Bananal and Bela Vista farms) in the Center-West region of Minas Gerais, Brazil. This study introduces a new topical formulation containing 3.0% Fluazuron, 1.25% Fipronil, and 0.5% Eprinomectin, which has demonstrated high efficacy against R. microplus in both natural (97%) and experimental (95%) infestations. Additionally, the formulation was effective as a larvicide against D. hominis (98%) and C. hominivorax (100%), as well as against H. irritans (98%) and as an anthelmintic (97%). Its broad-spectrum activity and prolonged efficacy make it a tool for managing parasitic infestations in cattle. However, the potential for resistance development and the need for strategic application highlight the importance of integrated control programs that combine chemical and nonchemical approaches to ensure sustainable parasite management.