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Effects of gonadectomy on prolactin and LH secretion and the pituitary-thyroid axis in male dogs

dc.contributor.authorGuenzel-Apel, A.-R.
dc.contributor.authorSeefeldt, A.
dc.contributor.authorEschricht, F. M.
dc.contributor.authorUrhausen, C.
dc.contributor.authorKramer, S.
dc.contributor.authorMischke, R.
dc.contributor.authorHoppen, H. -O.
dc.contributor.authorBeyerbach, M.
dc.contributor.authorKoivisto, M. [UNESP]
dc.contributor.authorDieleman, S. J.
dc.contributor.institutionUniv Vet Med Hannover
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Utrecht
dc.date.accessioned2014-05-20T15:31:19Z
dc.date.available2014-05-20T15:31:19Z
dc.date.issued2009-03-15
dc.description.abstractThe effects of gonadectomy on the secretion of prolactin, LH, TSH, and thyroxine were investigated. Blood serum hormone concentrations were analysed before and at 20, 120, and 180 min after a single iv TRH injection in each of eight healthy intact and castrated male beagle dogs before (control) and after 4-week treatment with the dopamine-2 receptor agonist cabergoline. Under control conditions the mean prolactin, TSH, and thyroxine concentrations were similar in intact and gonadectomised dogs, and administration of TRH provoked a significant (p < 0.01) increase in concentrations of the three hormones. The overall inhibitory effect of cabergoline treatment on prolactin secretion was more pronounced in the castrated dogs compared with the intact group. Cabergoline significantly suppressed the TRH-induced prolactin increase in each group (p < 0.01). Corresponding TRH-stimulated TSH concentrations were not affected by cabergoline. In the gonadectomised dogs, thyroxine concentrations before and at 120 and 180 min after TRH injection were significantly lower than under control conditions. LH concentrations were always higher (p < 0.01) in gonadectomised dogs compared with the intact dogs, but appeared to be affected neither by TRH nor by cabergoline administration. It can thus be concluded from the results, that gonadectomy does not result in hyperprolactinaemia in male dogs, while LH concentrations are significantly increased due to missing androgen feedback. Thyroid function remains unaffected by gonadectomy. Testicular steroids appear to interact with central dopaminergic and probably other neuroendocrine mechanisms regulating the secretion of prolactin, TSH, and thyroxine. Thus, long-term dopamine-2 receptor agonistic treatment may lead to a hypothyroid condition in castrated male dogs. (c) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Vet Med Hannover, Unit Reprod Med Clin, Small Anim Clin, D-30545 Hannover, Germany
dc.description.affiliationUniv Vet Med Hannover, Dept Endocrinol, D-30545 Hannover, Germany
dc.description.affiliationUniv Vet Med Hannover, Dept Biometry Epidemiol & Informat Proc, D-30545 Hannover, Germany
dc.description.affiliationSão Paulo State Univ, FMVA, Aracatuba, SP, Brazil
dc.description.affiliationUniv Utrecht, Fac Vet Med, Dept Farm Anim Hlth, Utrecht, Netherlands
dc.description.affiliationUnespSão Paulo State Univ, FMVA, Aracatuba, SP, Brazil
dc.format.extent746-753
dc.identifierhttp://dx.doi.org/10.1016/j.theriogenology.2008.09.047
dc.identifier.citationTheriogenology. New York: Elsevier B.V., v. 71, n. 5, p. 746-753, 2009.
dc.identifier.doi10.1016/j.theriogenology.2008.09.047
dc.identifier.issn0093-691X
dc.identifier.urihttp://hdl.handle.net/11449/40485
dc.identifier.wosWOS:000263808800004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofTheriogenology
dc.relation.ispartofjcr2.136
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectGonadectomyen
dc.subjectProlactinen
dc.subjectThyroxineen
dc.subjectDopamineen
dc.subjectTRHen
dc.titleEffects of gonadectomy on prolactin and LH secretion and the pituitary-thyroid axis in male dogsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
unesp.departmentClínica, Cirurgia e Reprodução Animal - FMVApt

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