Publication: Cardiac remodeling induced by smoking: concepts, relevance, and potential mechanisms
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Coadvisor
Graduate program
Undergraduate course
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Volume Title
Publisher
Inflammation & Allergy Drug Targets
Type
Article
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Acesso restrito
Abstract
Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke exposure is recognized as one of these insults. Indeed, tobacco smoke exposure induces the enlargement of the left-sided cardiac chambers, myocardial hypertrophy, and ventricular dysfunction. Potential mechanisms for these alterations include hemodynamic and neurohormonal changes, oxidative stress, inflammation, nitric oxide bioavailability, matrix metalloproteinases and mitogen-activated protein kinase activation. This review will focus on the concepts, relevance, and potential mechanisms of cardiac remodeling induced by tobacco smoke.
Description
Keywords
Matrix metalloproteinases, Oxidative stress, Tobacco smoke exposure, Ventricular remodeling, Cardiac Remodeling, Heart size, Myocardial hypertrophy, Ventricular dysfunction, Hemodynamic, Neurohormonal changes, Oxidative stress, Inflammation, Mitogen-activated protein kinase activation
Language
English
Citation
Inflammation & Allergy Drug Targets, v. 11, n. 6, p. 442-447, 2012.
