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Carious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children's Saliva

dc.contributor.authorAraujo, Heitor Ceolin [UNESP]
dc.contributor.authorNakamune, Ana Cláudia Melo Stevanato [UNESP]
dc.contributor.authorGarcia, Wilson Galhego [UNESP]
dc.contributor.authorPessan, Juliano Pelim [UNESP]
dc.contributor.authorAntoniali, Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T02:35:43Z
dc.date.available2020-12-12T02:35:43Z
dc.date.issued2020-01-01
dc.description.abstractOxidative stress biomarkers can be found at detectable concentrations in saliva. These salivary biomarkers reflect specific oxidation pathways associated with caries and periodontitis. Our study evaluated the influence of dental caries severity (assessed using the ICCMS™ criteria) on the levels of oxidative stress biomarkers in saliva from children. Unstimulated saliva samples were collected from patients (from one to three years old) in a day care center in Birigui, SP, Brazil, two hours after fasting. Children were divided into four groups (n=30/group), according to caries severity: caries free (group A), early carious lesions (group B), moderate carious lesions (group C), and advanced carious lesions (group D). The following salivary biomarkers were determined: total proteins (TP), measured by the Lowry method; oxidative damage, measured by the TBARS method; total antioxidant capacity (TAC); superoxide dismutase (SOD) enzymatic antioxidant activity; and uric acid (UA) non-enzymatic antioxidant activity. Data were analyzed by ANOVA, followed by the Student-Newman-Keuls test, Pearson and Spearman correlation coefficients, and multivariable linear regression (p<0.05). TP, TAC, SOD enzymatic antioxidant activity, and UA non-enzymatic antioxidant activity increased with caries severity, consequently reducing salivary oxidative damage. It was concluded that higher caries severity increases salivary antioxidant system activity, with consequent reduction in salivary oxidative damage.en
dc.description.affiliationGraduate Program in Dental Science São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationDepartment of Pediatric Dentistry and Public Health São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationMulticenter Graduate Program in Physiological Sciences São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationUnespGraduate Program in Dental Science São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationUnespDepartment of Pediatric Dentistry and Public Health São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationUnespMulticenter Graduate Program in Physiological Sciences São Paulo State University (UNESP) School of Dentistry
dc.description.affiliationUnespDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry
dc.identifierhttp://dx.doi.org/10.1155/2020/3695683
dc.identifier.citationOxidative Medicine and Cellular Longevity, v. 2020.
dc.identifier.doi10.1155/2020/3695683
dc.identifier.issn1942-0994
dc.identifier.issn1942-0900
dc.identifier.scopus2-s2.0-85079411070
dc.identifier.urihttp://hdl.handle.net/11449/201557
dc.language.isoeng
dc.relation.ispartofOxidative Medicine and Cellular Longevity
dc.sourceScopus
dc.titleCarious Lesion Severity Induces Higher Antioxidant System Activity and Consequently Reduces Oxidative Damage in Children's Salivaen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication8b3335a4-1163-438a-a0e2-921a46e0380d
relation.isOrgUnitOfPublication.latestForDiscovery8b3335a4-1163-438a-a0e2-921a46e0380d
unesp.author.orcid0000-0002-0315-6161 0000-0002-0315-6161 0000-0002-0315-6161 0000-0002-0315-6161[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentCiências Básicas - FOApt

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