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In vivo evaluation of the inflammatory response and IL-6 immunoexpression promoted by Biodentine and MTA Angelus

dc.contributor.authorFonseca, T. S. da [UNESP]
dc.contributor.authorSilva, G. F. da [UNESP]
dc.contributor.authorTanomaru Filho, Mario [UNESP]
dc.contributor.authorSasso-Cerri, E. [UNESP]
dc.contributor.authorTanomaru, Juliane Maria Guerreiro [UNESP]
dc.contributor.authorCerri, Paulo Sérgio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-06T16:13:29Z
dc.date.available2015-08-06T16:13:29Z
dc.date.issued2015
dc.description.abstractAim To evaluate the inflammatory process induced by Biodentine and mineral trioxide aggregate (MTA) in rat subcutaneous tissues. Methodology A polyethylene tube filled with Biodentine (n = 20) or MTA (n = 20) was placed into the dorsal subcutaneous of forty male rats; in the control group (CG; n = 20), empty tubes were implanted. After 7, 15, 30 and 60 days, the polyethylene tubes surrounded by connective tissue were fixed and embedded in paraffin. The number of inflammatory cells was estimated in HE-stained sections; numerical density of interleukin-6 (IL-6)-immunolabelled cells was also performed. The differences amongst the groups were analysed statistically by Tukey's test (P ≤ 0.05). Results A high number of inflammatory cells and IL-6-positive cells were observed at 7 days, in all groups; however, in the Biodentine group, the number of inflammatory cells and IL-6-immunolabelled cells was significantly higher (P ≤ 0.05) in comparison with the other groups at 7 and 15 days. In the capsules of animals from all groups, a gradual and significant reduction (P ≤ 0.05) of these parameters was seen over time. At 60 days, the capsules exhibited numerous fibroblasts and bundles of collagen fibres; in addition, the number of IL-6-positive cells was not significantly different amongst Biodentine, MTA and control groups. Conclusions There was a significant regression in the inflammatory reaction in the capsules indicating, therefore, that Biodentine is a biocompatible material.en
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Odontologia Restauradora, Faculdade de Odontologia de Araraquara, Araraquara, Rua Humaitá nº 1680, Centro, CEP 14801-903, SP, Brasil
dc.description.affiliationUnespDepartment of Restorative Dentistry
dc.description.affiliationUnespDepartment of Mophology
dc.identifierhttp://onlinelibrary.wiley.com/doi/10.1111/iej.12435/abstract
dc.identifier.citationInternational Endodontic Journal, v. 48, n. 5, 2015.
dc.identifier.doi10.1111/iej.12435
dc.identifier.issn0143-2885
dc.identifier.lattes2665211298584751
dc.identifier.lattes3278495911207882
dc.identifier.lattes4455630076841302
dc.identifier.orcid0000-0001-5756-5828
dc.identifier.urihttp://hdl.handle.net/11449/125929
dc.language.isoeng
dc.relation.ispartofInternational Endodontic Journal
dc.relation.ispartofjcr3.015
dc.relation.ispartofsjr1,791
dc.rights.accessRightsAcesso restritopt
dc.sourceCurrículo Lattes
dc.subjectBiocompatibilityen
dc.subjectBiodentineen
dc.subjectImmunohistochemistryen
dc.subjectInterleukin-6en
dc.subjectMTA Angelusen
dc.titleIn vivo evaluation of the inflammatory response and IL-6 immunoexpression promoted by Biodentine and MTA Angelusen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublication901124bf-5736-4432-b057-7c29dec84b50
relation.isDepartmentOfPublication.latestForDiscovery901124bf-5736-4432-b057-7c29dec84b50
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.author.lattes2665211298584751
unesp.author.lattes3278495911207882[6]
unesp.author.lattes4455630076841302
unesp.author.orcid0000-0001-5756-5828[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentOdontologia Restauradora - FOARpt

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