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Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cells

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dc.contributor.authorGanassin, Rayane
dc.contributor.authorDa Silva, Victor Carlos Mello
dc.contributor.authorAraujo, Victor Hugo Sousa
dc.contributor.authorTavares, Giulia Rosa
dc.contributor.authorDa Silva, Patrícia Bento
dc.contributor.authorCáceres-Vélez, Paolin Rocio
dc.contributor.authorPorcel, Joaquin E Martínez
dc.contributor.authorRodrigues, Mosar Corrêa
dc.contributor.authorAndreozzi, Patrizia
dc.contributor.authorFernandes, Richard Perosa [UNESP]
dc.contributor.authorFonseca-Santos, Bruno
dc.contributor.authorMoya, Sergio
dc.contributor.authorAzevedo, Ricardo Bentes
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.authorMuehlmann, Luis Alexandre
dc.contributor.institutionUniversity of Brasilia
dc.contributor.institutionCenter for Cooperative Research in Biomaterials (CIC BiomaGUNE)
dc.contributor.institutionThe University of Melbourne
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2022-05-01T13:41:27Z
dc.date.available2022-05-01T13:41:27Z
dc.date.issued2022-02-01
dc.description.abstractAim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN-Cs with a high curcumin-loading capacity were obtained. The SLN-Cs were more toxic to CT26 than free curcumin. Fluorescence microscopy images showed the SLN-Cs to be taken up by CT26 cells in vitro. Conclusion: These results indicate that SLN-Cs are suitable carriers of curcumin in aqueous media.en
dc.description.affiliationLaboratory of Nanoscience and Immunology Faculty of Ceilandia University of Brasilia, DF
dc.description.affiliationDepartment of Genetics and Morphology Institute of Biological Sciences University of Brasilia
dc.description.affiliationSoft Matter Laboratory Center for Cooperative Research in Biomaterials (CIC BiomaGUNE)
dc.description.affiliationSchool of Biosciences The University of Melbourne
dc.description.affiliationLaboratory of Thermal Analysis Ivo Giolitto Chemical Institute São Paulo State University São Paulo, SP
dc.description.affiliationUniversity of Campinas (UNICAMP), São Paulo
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespLaboratory of Thermal Analysis Ivo Giolitto Chemical Institute São Paulo State University São Paulo, SP
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.format.extent167-179
dc.identifierhttp://dx.doi.org/10.2217/nnm-2021-0229
dc.identifier.citationNanomedicine, v. 17, n. 3, p. 167-179, 2022.
dc.identifier.doi10.2217/nnm-2021-0229
dc.identifier.issn1748-6963
dc.identifier.issn1743-5889
dc.identifier.scopus2-s2.0-85123968657
dc.identifier.urihttp://hdl.handle.net/11449/234097
dc.language.isoeng
dc.relation.ispartofNanomedicine
dc.sourceScopus
dc.subjectcancer
dc.subjectcolloid
dc.subjectcolon adenocarcinoma
dc.subjectdrug delivery
dc.subjectmurumuru butter
dc.titleSolid lipid nanoparticles loaded with curcumin: Development and in vitro toxicity against CT26 cellsen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas