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Osteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomas

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dc.contributor.authorMonteiro, Lidianne N.
dc.contributor.authorSalgado, Breno S.
dc.contributor.authorOliveira, Deilson E. [UNESP]
dc.contributor.authorRivera-Calderon, Luis G.
dc.contributor.authorMontoya-Flórez, Luis M.
dc.contributor.authorSanctis, Paula [UNESP]
dc.contributor.authorRocha, Noeme S. [UNESP]
dc.contributor.institutionFaculdade Multivix
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.contributor.institutionSede Popayan
dc.date.accessioned2020-12-12T02:16:01Z
dc.date.available2020-12-12T02:16:01Z
dc.date.issued2020-03-01
dc.description.abstractOsteopontin is a glycophosphoprotein implicated in different physiologic and pathologic processes and is known to be involved in progression and metastasis of various cancers in humans, but this relation is still little explored in the veterinary. The aim was to evaluate the expression of osteopontin in canine mammary carcinomas and its relation with well-established canine mammary tumor biomarkers. For that, expression of OPN, EGFR, HER2, and c-Kit were evaluated along with Ki67 rate in 43 mammary carcinomas. Osteopontin was demonstrated to be expressed by neoplastic epithelial cells in all carcinomas as well as in stromal cells from the tumor microenvironment. Relation between high osteopontin expression and EGFR positivity (P<0.001) and HER2 overexpression (P=0.012) was demonstrated. In conclusion, high OPN expression seems to be related to poor prognosis and MAPK pathway activation, given the association with EGFR and HER2, members of the MAPK signaling pathway.en
dc.description.affiliationConsultoria Diagnóstica em Patologia Veterinária (CODIVET) Faculdade Multivix Campus Vitoria, Rua José Alves 135
dc.description.affiliationDepartamento de Clinica Veterinária Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Rua Prof. Dr. Valter Maurício Corrêa s/n
dc.description.affiliationFaculdade de Medicina Veterinária Universidade Federal do Espírito Santo (UFES), Av. Fernando Ferrari 514
dc.description.affiliationFaculdade de Medicina Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Av. Prof. Mário Rubens Guimarães Montenegro s/n
dc.description.affiliationFacultad de Medicina Veterinaria Universidad Antonio Nariño Sede Popayan, Calle 53 #9-35
dc.description.affiliationUnespDepartamento de Clinica Veterinária Faculdade de Medicina Veterinária e Zootecnia (FMVZ) Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Rua Prof. Dr. Valter Maurício Corrêa s/n
dc.description.affiliationUnespFaculdade de Medicina Universidade Estadual Paulista “Júlio de Mesquita Filho” (Unesp), Av. Prof. Mário Rubens Guimarães Montenegro s/n
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2010/51596-2
dc.description.sponsorshipIdCNPq: 479178/2010-0
dc.format.extent210-219
dc.identifierhttp://dx.doi.org/10.1590/1678-5150-PVB-6489
dc.identifier.citationPesquisa Veterinaria Brasileira, v. 40, n. 3, p. 210-219, 2020.
dc.identifier.doi10.1590/1678-5150-PVB-6489
dc.identifier.fileS0100-736X2020000300210.pdf
dc.identifier.issn1678-5150
dc.identifier.issn0100-736X
dc.identifier.scieloS0100-736X2020000300210
dc.identifier.scopus2-s2.0-85088277890
dc.identifier.urihttp://hdl.handle.net/11449/200786
dc.language.isoeng
dc.relation.ispartofPesquisa Veterinaria Brasileira
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCancer
dc.subjectCanine mammary carcinomas
dc.subjectDogs
dc.subjectEpidermal growth factor receptor
dc.subjectHuman epidermal growth factor receptor 2
dc.subjectImmunohistochemistry
dc.subjectOsteopontin expression
dc.subjectPrognostic biomarkers
dc.titleOsteopontin expression and its relationship with prognostic biomarkers in canine mammary carcinomasen
dc.titleExpessão de osteopontina e sua relação com biomarcadores prognóstico nos carcinomas mamários caninospt
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentClínica Veterinária - FMVZpt

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Botucatu - FMVZ - Faculdade de Medicina Veterinária e Zootecnia