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Bacille Calmette-Guérin/DNAhsp65 prime-boost is protective against diabetes in non-obese diabetic mice but not in the streptozotocin model of type 1 diabetes

dc.contributor.authorDa Rosa, L. C. [UNESP]
dc.contributor.authorChiuso-Minicucci, F. [UNESP]
dc.contributor.authorZorzella-Pezavento, S. F G [UNESP]
dc.contributor.authorFrança, T. G D [UNESP]
dc.contributor.authorIshikawa, L. L W [UNESP]
dc.contributor.authorColavite, P. M. [UNESP]
dc.contributor.authorBalbino, B. [UNESP]
dc.contributor.authorTavares, L. C B [UNESP]
dc.contributor.authorSilva, C. L.
dc.contributor.authorMarques, C.
dc.contributor.authorIkoma, M. R V
dc.contributor.authorSartori, A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionLaboratório de Citometria de Fluxo
dc.date.accessioned2014-05-27T11:30:33Z
dc.date.available2014-05-27T11:30:33Z
dc.date.issued2013-09-01
dc.description.abstractType I diabetes is a disease caused by autoimmune destruction of the beta cells in the pancreas that leads to a deficiency in insulin production. The aim of this study was to evaluate the prophylactic potential of a prime-boost strategy involving bacille Calmette-Guérin (BCG) and the pVAXhsp65 vaccine (BCG/DNAhsp65) in diabetes induced by streptozotocin (STZ) in C57BL/6 mice and also in spontaneous type 1 diabetes in non-obese diabetic (NOD) mice. BCG/DNAhsp65 vaccination in NOD mice determined weight gain, protection against hyperglycaemia, decreased islet inflammation, higher levels of cytokine production by the spleen and a reduced number of regulatory T cells in the spleen compared with non-immunized NOD mice. In the STZ model, however, there was no significant difference in the clinical parameters. Although this vaccination strategy did not protect mice in the STZ model, it was very effective in NOD mice. This is the first report demonstrating that a prime-boost strategy could be explored as an immunomodulatory procedure in autoimmune diseases. © 2013 British Society for Immunology.en
dc.description.affiliationDepartment of Microbiology and Immunology Biosciences Institute Universidade Estadual Paulista (UNESP), Botucatu
dc.description.affiliationDepartment of Biochemistry and Immunology University of São Paulo (USP), Ribeirão Preto
dc.description.affiliationFundação Dr Amaral Carvalho Laboratório de Citometria de Fluxo, Jaú, São Paulo
dc.description.affiliationUnespDepartment of Microbiology and Immunology Biosciences Institute Universidade Estadual Paulista (UNESP), Botucatu
dc.format.extent430-437
dc.identifierhttp://dx.doi.org/10.1111/cei.12140
dc.identifier.citationClinical and Experimental Immunology, v. 173, n. 3, p. 430-437, 2013.
dc.identifier.doi10.1111/cei.12140
dc.identifier.issn0009-9104
dc.identifier.issn1365-2249
dc.identifier.lattes4977572416129527
dc.identifier.scopus2-s2.0-84881512633
dc.identifier.urihttp://hdl.handle.net/11449/76440
dc.identifier.wosWOS:000322774800006
dc.language.isoeng
dc.relation.ispartofClinical and Experimental Immunology
dc.relation.ispartofjcr3.542
dc.relation.ispartofsjr1,431
dc.relation.ispartofsjr1,431
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBCG
dc.subjectHsp65
dc.subjectImmunomodulation
dc.subjectNOD mice
dc.subjectType 1 diabetes
dc.subjectBCG vaccine
dc.subjectDNA vaccine
dc.subjectpVAXhsp65 vaccine
dc.subjectstreptozocin
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectBCG vaccination
dc.subjectcontrolled study
dc.subjectcytokine production
dc.subjectfemale
dc.subjecthyperglycemia
dc.subjectimmunomodulation
dc.subjectinsulin dependent diabetes mellitus
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectregulatory T lymphocyte
dc.subjectspleen
dc.subjectweight gain
dc.titleBacille Calmette-Guérin/DNAhsp65 prime-boost is protective against diabetes in non-obese diabetic mice but not in the streptozotocin model of type 1 diabetesen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dspace.entity.typePublication
unesp.author.lattes4977572416129527[12]
unesp.author.orcid0000-0002-0043-4568[9]
unesp.author.orcid0000-0001-8209-8942[8]
unesp.author.orcid0000-0003-3481-2181[5]
unesp.author.orcid0000-0001-9030-0768[3]
unesp.author.orcid0000-0003-4557-3331[12]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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