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In vitro drug permeation from chitosan pellets

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dc.contributor.authorFerrari, Priscileila C. [UNESP]
dc.contributor.authorSouza, Fagner M.
dc.contributor.authorGiorgetti, Leandro
dc.contributor.authorOliveira, Giselle F. [UNESP]
dc.contributor.authorChaud, Marco V.
dc.contributor.authorFerraz, Humberto G.
dc.contributor.authorEvangelista, Raul Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSorocaba Univ
dc.date.accessioned2014-05-20T13:24:49Z
dc.date.available2014-05-20T13:24:49Z
dc.date.issued2012-03-01
dc.description.abstractThe purpose of this study was to prepare and characterize coated pellets for controlled drug delivery. The influence of chitosan (CS) in pellets was evaluated by swelling, in vitro drug release and intestinal permeation assays. Pellets were coated with an enteric polymer, Kollicoat (R) MAE 30 DP, in a fluidized-bed apparatus and the coating formulations were based on a factorial design. Metronidazole (MT) released from coated and uncoated pellets were assessed by dissolution method using Apparatus I. Intestinal permeation was evaluated by everted intestinal sac model in rats, used to study the absorption of MT from coated pellets containing CS or not through the intestinal tissue. Although the film coating avoided drug dissolution in gastric medium, the overall drug release and intestinal permeation were dependent on the presence of CS. Thus, pellets containing CS show potential as a system for controlled drug delivery. (C) 2011 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Drugs & Pharmaceut, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Pharm, Sch Pharmaceut Sci, BR-05508000 São Paulo, Brazil
dc.description.affiliationSorocaba Univ, Pharmaceut Sci Postgrad Program, BR-18023000 Sorocaba, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Drugs & Pharmaceut, Sch Pharmaceut Sci, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent2526-2531
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2011.11.027
dc.identifier.citationCarbohydrate Polymers. Oxford: Elsevier B.V., v. 87, n. 4, p. 2526-2531, 2012.
dc.identifier.doi10.1016/j.carbpol.2011.11.027
dc.identifier.issn0144-8617
dc.identifier.lattes5361569184579557
dc.identifier.urihttp://hdl.handle.net/11449/7796
dc.identifier.wosWOS:000299969800022
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCarbohydrate Polymers
dc.relation.ispartofjcr5.158
dc.relation.ispartofsjr1,428
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectPelletsen
dc.subjectChitosanen
dc.subjectEnteric coatingen
dc.subjectMetronidazoleen
dc.subjectControlled drug deliveryen
dc.subjectEverted intestinal sac modelen
dc.titleIn vitro drug permeation from chitosan pelletsen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublicatione214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isDepartmentOfPublication.latestForDiscoverye214da1b-9929-4ae9-b8fd-655e9bfeda4b
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes5361569184579557
unesp.author.orcid0000-0003-3618-8415[5]
unesp.author.orcid0000-0002-4285-6646[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentFármacos e Medicamentos - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas