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Diagnostic index of 3D osteoarthritic changes in TMJ condylar morphology

dc.contributor.authorGomes, Liliane R. [UNESP]
dc.contributor.authorGomes, Marcelo
dc.contributor.authorJung, Bryan
dc.contributor.authorPaniagua, Beatriz
dc.contributor.authorRuellas, Antonio C.
dc.contributor.authorGoncąlves, Joaõ Roberto [UNESP]
dc.contributor.authorStyner, Martin A.
dc.contributor.authorWolford, Larry
dc.contributor.authorCevidanes, Lucia
dc.contributor.institutionUniversity of Michigan
dc.contributor.institutionUniversity of North Carolina
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionMedical Center
dc.date.accessioned2018-12-11T17:26:22Z
dc.date.available2018-12-11T17:26:22Z
dc.date.issued2015-01-01
dc.description.abstractThe aim of this study was to investigate imaging statistical approaches for classifying 3D osteoarthritic morphological variations among 169 Temporomandibular Joint (TMJ) condyles. Cone beam Computed Tomography (CBCT) scans were acquired from 69 patients with long-term TMJ Osteoarthritis (OA) (39.1 ± 15.7 years), 15 patients at initial diagnosis of OA (44.9 ± 14.8 years) and 7 healthy controls (43 ± 12.4 years). 3D surface models of the condyles were constructed and Shape Correspondence was used to establish correspondent points on each model. The statistical framework included a multivariate analysis of covariance (MANCOVA) and Direction-Projection-Permutation (DiProPerm) for testing statistical significance of the differences between healthy control and the OA group determined by clinical and radiographic diagnoses. Unsupervised classification using hierarchical agglomerative clustering (HAC) was then conducted. Condylar morphology in OA and healthy subjects varied widely. Compared with healthy controls, OA average condyle was statistically significantly smaller in all dimensions except its anterior surface. Significant flattening of the lateral pole was noticed at initial diagnosis (p < 0.05). It was observed areas of 3.88 mm bone resorption at the superior surface and 3.10 mm bone apposition at the anterior aspect of the long-term OA average model. 1000 permutation statistics of DiProPerm supported a significant difference between the healthy control group and OA group (t = 6.7, empirical p-value = 0.001). Clinically meaningful unsupervised classification of TMJ condylar morphology determined a preliminary diagnostic index of 3D osteoarthritic changes, which may be the first step towards a more targeted diagnosis of this condition.en
dc.description.affiliationUniversity of Michigan, 1011 North University Avenue
dc.description.affiliationUniversity of North Carolina, 101 Manning Drive
dc.description.affiliationUNESP Univ Estadual Paulista, 1680 Humaita Street
dc.description.affiliationBaylor University Medical Center, 3501 Junius Street
dc.description.affiliationUnespUNESP Univ Estadual Paulista, 1680 Humaita Street
dc.identifierhttp://dx.doi.org/10.1117/12.2082226
dc.identifier.citationProgress in Biomedical Optics and Imaging - Proceedings of SPIE, v. 9414.
dc.identifier.doi10.1117/12.2082226
dc.identifier.issn1605-7422
dc.identifier.scopus2-s2.0-84948799588
dc.identifier.urihttp://hdl.handle.net/11449/177624
dc.language.isoeng
dc.relation.ispartofProgress in Biomedical Optics and Imaging - Proceedings of SPIE
dc.relation.ispartofsjr0,243
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subject3D imaging
dc.subjectBone Overgrowth
dc.subjectBone Resorption
dc.subjectOsteoarthritis
dc.subjectTemporomandibular Joint Disorders
dc.titleDiagnostic index of 3D osteoarthritic changes in TMJ condylar morphologyen
dc.typeTrabalho apresentado em eventopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationca4c0298-cd82-48ee-a9c8-c97704bac2b0
relation.isOrgUnitOfPublication.latestForDiscoveryca4c0298-cd82-48ee-a9c8-c97704bac2b0
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentClínica Infantil - FOARpt

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