Effect of Brazilian propolis on experimental hepatotoxicity in rats
Carregando...
Data
Orientador
Coorientador
Pós-graduação
Curso de graduação
Título da Revista
ISSN da Revista
Título de Volume
Editor
Tipo
Artigo
Direito de acesso
Acesso restrito
Resumo
Propolis (bee glue) is one of the major hive products of bees and is rich in flavonoids, which are known for their antioxidant activities. The aim of this study was to evaluate the hepatoprotective effects of the ethanolic extract of propolis (EEP) against experimental carbon tetrachloride (CCl 4)-induced liver toxicity in rats by means of biochemical indices. The animals were divided into 4 groups: GI= received mineral oil; GII= CCl 4(4mL/kg; Lp., single dose) treated; GIII= CCl4 (4mL/kg; i.p., single dose) treatment followed by ethanolic extract of propolis (100mg/kg) for gavage from the species Tetragonisca angustula, daily for 3 days and GIV= CCl4 (4mL/kg; i.p., single dose) treatment followed by ethanolic extract of propolis (100mg/kg) for gavage from the species Nannotrigonea testaceicornes, daily, for 3 days. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), cholesterol and triacylglycerols were estimated after 3 days. CCl 4 caused a maximum increase (p<0,01) above biochemical parameters. As compared to CCl4 group (GII), the EEP (GIII and GIV) showed reduction in cholesterol, triacylglycerol, ALT, AST and alkaline phosphatase activity in the serum. In conclusion, these data indicate that EEP improved the dyslipidaemia, moreover, significantly attenuated increases in serum ALT and AST activities in rats with liver damage induced by carbon tetrachloride.
Descrição
Palavras-chave
Biochemistry, Carbon tetrachloride, Hepatotoxicity, Propolis, Protection, alanine aminotransferase, alcohol, alkaline phosphatase, carbon tetrachloride, cholesterol, mineral oil, propolis, triacylglycerol, alanine aminotransferase blood level, alkaline phosphatase blood level, animal experiment, animal model, controlled study, drug effect, drug isolation, dyslipidemia, enzyme activity, feeding, liver protection, liver toxicity, male, medicinal plant, nannotrigonea testaceicornes, nonhuman, rat, tetragonisca angustula, triacylglycerol blood level
Idioma
Inglês
Citação
Revista de Ciencias Farmaceuticas, v. 25, n. 2, p. 85-89, 2004.