Publicação: Inhibitory effect of gallic acid and its esters on 2,2'-azobis(2-amidinopropane)hodrpchloride (AAPH)-induced hemolysis and depletion of intracellular glutathione in erythrocytes
dc.contributor.author | Ximenes, Valdecir Farias [UNESP] | |
dc.contributor.author | Lopes, Mariana G. [UNESP] | |
dc.contributor.author | Petrônio, Maicon Segalla [UNESP] | |
dc.contributor.author | Regasini, Luis Octavio [UNESP] | |
dc.contributor.author | Silva, Dulce Helena Siqueira [UNESP] | |
dc.contributor.author | Fonseca, Luiz Marcos da [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2016-01-28T16:56:18Z | |
dc.date.available | 2016-01-28T16:56:18Z | |
dc.date.issued | 2010 | |
dc.description.abstract | The protective effect of gallic acid and its esters, methyl, propyl, and lauryl gallate, against 2,2'-azobis(2-amidinopropane)hydrochloride (AAPH)-induced hemolysis and depletion of intracellular glutathione (GSH) in erythrocytes was studied. The inhibition of hemolysis was dose-dependent, and the esters were significantly more effective than gallic acid. Gallic acid and its esters were compared with regard to their reactivity to free radicals, using the DPPH and AAPH/pyranine free-cell assays, and no significant difference was obtained. Gallic acid and its esters not only failed to inhibit the depletion of intracellular GSH in erythrocytes induced by AAPH but exacerbated it. Similarly, the oxidation of GSH by AAPH or horseradish peroxidase/H(2)O(2) in cell-free systems was exacerbated by gallic acid or gallates. This property could be involved in the recent findings on pro-apoptotic and pro-oxidant activities of gallates in tumor cells. We provide evidence that lipophilicity and not only radical scavenger potency is an important factor regarding the efficiency of antihemolytic substances. | en |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara | |
dc.description.affiliation | Departamento de Química, Faculdade de Ciências, Unesp − Univ Estadual Paulista, Bauru, São Paulo (SP), CEP 17033-360, Brazil | |
dc.description.affiliation | Departamento de Química Orgânica, Instituto de Química, Unesp − Univ Estadual Paulista, Araraquara, São Paulo (SP), Brazil | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara | |
dc.description.affiliationUnesp | Departamento de Química, Faculdade de Ciências, Unesp − Univ Estadual Paulista, Bauru, São Paulo (SP), CEP 17033-360, Brazil | |
dc.description.affiliationUnesp | Departamento de Química Orgânica, Instituto de Química, Unesp − Univ Estadual Paulista, Araraquara, São Paulo (SP), Brazil | |
dc.format.extent | 5355-5362 | |
dc.identifier | http://pubs.acs.org/doi/abs/10.1021/jf100233y | |
dc.identifier.citation | Journal of Agricultural and Food Chemistry, v. 58, p. 5355-5362, 2010. | |
dc.identifier.doi | 10.1021/jf100233y | |
dc.identifier.issn | 0021-8561 | |
dc.identifier.lattes | 4419635633356792 | |
dc.identifier.lattes | 0992736452764550 | |
dc.identifier.lattes | 4702004904231248 | |
dc.identifier.lattes | 4066413997908572 | |
dc.identifier.orcid | 0000-0002-1516-7765 | |
dc.identifier.uri | http://hdl.handle.net/11449/133717 | |
dc.language.iso | eng | |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | |
dc.relation.ispartofjcr | 3.412 | |
dc.relation.ispartofsjr | 1,269 | |
dc.rights.accessRights | Acesso restrito | |
dc.source | Currículo Lattes | |
dc.subject | Gallic acid | en |
dc.subject | Gallates | en |
dc.subject | Erythrocytes | en |
dc.subject | Hemolysis | en |
dc.subject | Glutathione | en |
dc.subject | Peroxyl radical | en |
dc.subject | Antioxidant | en |
dc.subject | Pro-oxidant activity | en |
dc.title | Inhibitory effect of gallic acid and its esters on 2,2'-azobis(2-amidinopropane)hodrpchloride (AAPH)-induced hemolysis and depletion of intracellular glutathione in erythrocytes | en |
dc.type | Artigo | |
dspace.entity.type | Publication | |
unesp.author.lattes | 4419635633356792 | |
unesp.author.lattes | 0992736452764550 | |
unesp.author.lattes | 4702004904231248[5] | |
unesp.author.lattes | 4066413997908572 | |
unesp.author.orcid | 0000-0002-1516-7765[5] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.campus | Universidade Estadual Paulista (UNESP), Instituto de Química, Araraquara | pt |
unesp.department | Análises Clínicas - FCF | pt |
unesp.department | Química - FC | pt |
unesp.department | Química Orgânica - IQAR | pt |